Q9MLI6 · CYB_OPHHA
- ProteinCytochrome b
- GeneMT-CYB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids372 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Miscellaneous
Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
Cofactor
Note: Binds 2 heme b groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 89 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 174 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 188 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 193 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Elapinae > Ophiophagus
Accessions
- Primary accessionQ9MLI6
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-45 | Helical | ||||
Sequence: FGSMLLTCLAMQTLTGFFLAI | ||||||
Transmembrane | 69-90 | Helical | ||||
Sequence: WTMQNLHAIGASMFFICIYIHI | ||||||
Transmembrane | 105-125 | Helical | ||||
Sequence: WLSGITLLITLMATAFFGYVL | ||||||
Transmembrane | 170-190 | Helical | ||||
Sequence: FFALHFILPFIIISLTSIHII | ||||||
Transmembrane | 218-238 | Helical | ||||
Sequence: YKDMLMVTTMITLLFLILSFS | ||||||
Transmembrane | 280-300 | Helical | ||||
Sequence: LGGTLALLMSIAILMTTPFTH | ||||||
Transmembrane | 312-332 | Helical | ||||
Sequence: LTQILFWTLVATFITLTWTAT | ||||||
Transmembrane | 339-358 | Helical | ||||
Sequence: FIIISQMTSIFYFFFFIMNP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000061319 | 1-372 | Cytochrome b | |||
Sequence: MSNQHILLMSNLLPVGSNISTWWNFGSMLLTCLAMQTLTGFFLAIHYTANINLAFSSVIHITRDVPYGWTMQNLHAIGASMFFICIYIHIARGIYYGSYLNKEVWLSGITLLITLMATAFFGYVLPWGQMSFWAATVITNLLTAIPYLGTTLTTWLWGGFSINDPTLTRFFALHFILPFIIISLTSIHIILLHNEGSSNPPGTNSDIDKIPFHPYHSYKDMLMVTTMITLLFLILSFSPDLLNDPENFSKANPMITPQHIKPEWYFLFAYGILRSIPNKLGGTLALLMSIAILMTTPFTHTSYTRSMTFRPLTQILFWTLVATFITLTWTATKPVESPFIIISQMTSIFYFFFFIMNPILGWTENKIMMMND |
Interaction
Subunit
The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.
Structure
Sequence
- Sequence statusComplete
- Length372
- Mass (Da)42,399
- Last updated2000-10-01 v1
- Checksum105AC5D2224826D8