Q9HKM2 · PYRB_THEAC

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site56carbamoyl phosphate (UniProtKB | ChEBI)
Binding site57carbamoyl phosphate (UniProtKB | ChEBI)
Binding site85L-aspartate (UniProtKB | ChEBI)
Binding site106carbamoyl phosphate (UniProtKB | ChEBI)
Binding site134carbamoyl phosphate (UniProtKB | ChEBI)
Binding site137carbamoyl phosphate (UniProtKB | ChEBI)
Binding site167L-aspartate (UniProtKB | ChEBI)
Binding site227L-aspartate (UniProtKB | ChEBI)
Binding site266carbamoyl phosphate (UniProtKB | ChEBI)
Binding site267carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase catalytic subunit
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • Ordered locus names
      Ta0575

Organism names

Accessions

  • Primary accession
    Q9HKM2

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001132611-305Aspartate carbamoyltransferase catalytic subunit

Proteomic databases

Interaction

Subunit

Heterooligomer of catalytic and regulatory chains.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    34,398
  • Last updated
    2001-03-01 v1
  • Checksum
    9CD3D48571A7D718
MLKNRSVVSIEDVDIDDLNDLFDLSDSMLKTIEKGGSTDLLRNRIMATLFYEPSTRTRLSFESAMHRLGGSVITVSDVKTSSVAKGETLADTIRMASSYSDIIVIRHPLEGAARLASKFANKPVINAGDGSGQHPTQTILDLYTIKRETGSIDGKTITMVGDLRYGRTIHSLIIALSRFDVRINLVSPQILKLPEYVLTKIGDRSRIMEYDDLSKVIEDTDVLYVTRIQKERFSDQNEYQSVIGSYSVDRDLVSRMKKDAIIMHPLPRIDEIKPEVDELPQARYFKQAYYGVPVRMALIYRILGD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL445064
EMBL· GenBank· DDBJ
CAC11715.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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