Q9GSD7 · CRT_PLAKN

  • Protein
    Putative chloroquine resistance transporter
  • Gene
    CRT
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Nutrient transporter (By similarity).
Involved in maintaining the osmotic homeostasis of the digestive vacuole (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvacuolar membrane
Molecular Functionxenobiotic transmembrane transporter activity
Biological Processamino acid transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Putative chloroquine resistance transporter
  • Alternative names
    • Probable transporter cg10 (pkcg10)
    • pfcrt homolog

Gene names

    • Name
      CRT
    • Synonyms
      CG10

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    Q9GSD7

Organism-specific databases

Subcellular Location

Vacuole membrane
; Multi-pass membrane protein
Note: Localizes to the parasite digestive vacuole, the site of chloroquine action.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-57Cytoplasmic
Transmembrane58-78Helical
Topological domain79-89Vacuolar
Transmembrane90-110Helical
Topological domain111-124Cytoplasmic
Transmembrane125-145Helical
Topological domain146-153Vacuolar
Transmembrane154-174Helical
Topological domain175-179Cytoplasmic
Transmembrane180-200Helical
Topological domain201-208Vacuolar
Transmembrane209-229Helical
Topological domain230-246Cytoplasmic
Transmembrane247-267Helical
Topological domain268-316Vacuolar
Transmembrane317-337Helical
Topological domain338-345Cytoplasmic
Transmembrane346-366Helical
Topological domain367-376Vacuolar
Transmembrane377-397Helical
Topological domain398-424Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00003853591-424Putative chloroquine resistance transporter
Glycosylation87N-linked (GlcNAc...) asparagine
Disulfide bond288↔311
Disulfide bond300↔308

Keywords

PTM databases

Structure

Family & Domains

Sequence similarities

Belongs to the CRT-like transporter family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    424
  • Mass (Da)
    48,673
  • Last updated
    2001-03-01 v1
  • Checksum
    E3F2872D08898753
MKILKKKKKGNQQIVPDERYRELDSHAPNENEIADEAPMSRKILYYLKLVYHEIRENITIYLLIILYLCVCVMNKIMAKRTLKKIGNYSFVTSETHNTICMVVFFSLYFIFGRRVTSAKERHQNFGLQFLLISLLDACSVIIAFIGLTRTTGNIQSFVMQLSIPINMFFCFLILRYRYHLFNYVGASIIVLTIAIVEFILSFETQEENSIVFNLVLIASLIPMSFSNMTREIVFKKYKINILRLNAVVSFFQIFTSCLMLPMYTLPFLKQINLPFSEIGTNIKNGFRCLILGQNTIVENCGLGMAKMCDDCEGAWKTFLAYSFFNICDNLITSFIIDKFSTMTYTIVSCIQGPAIAIAYYFKFLAGDAVMKPRVLDFVTLFGYLFGSIIYRVGNIILEKKKMMEAGNDDDSEGELTNAESIITQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF314646
EMBL· GenBank· DDBJ
AAG27735.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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