Q9BLM6 · TOR_SCHHA
- ProteinTetraspanning orphan receptor
- GeneTOR
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids313 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Cell surface receptor that binds to human complement C2a protein. This results in inhibition of the classical and lectin pathways of complement activation, probably due to interference with binding of C2a to C4b and interference with cleavage by C1 or MASP2 such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.
Miscellaneous
Specifically and strongly recognized by a serum from baboons vaccinated with irradiated parasite. Potential vaccine candidate molecule.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | lysosomal membrane | |
Cellular Component | plasma membrane |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameTetraspanning orphan receptor
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma
Accessions
- Primary accessionQ9BLM6
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Located on the surface tegumental plasma membrane, and tegumental surface pits of adult schistosomes so in contact with host blood plasma.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-54 | Extracellular | ||||
Sequence: PQCESETNFHYDIPPGYKDDVLVDVNNMSPSLVSDTQKHERGSHEVKIKHFSPY | ||||||
Transmembrane | 55-75 | Helical | ||||
Sequence: IAVCVTTFSLAFCCFMVHAAI | ||||||
Topological domain | 76-82 | Cytoplasmic | ||||
Sequence: TRQPTHL | ||||||
Transmembrane | 83-103 | Helical | ||||
Sequence: LPFFFIQVFDLIICLIHILGF | ||||||
Topological domain | 104-129 | Extracellular | ||||
Sequence: MSSTSDIRLVIHTKTGPIYIKSTGLT | ||||||
Transmembrane | 130-150 | Helical | ||||
Sequence: FIILSISCMMLAFKAYCLGMV | ||||||
Topological domain | 151-313 | Cytoplasmic | ||||
Sequence: WDCYKYLMLNRRGNLLDDWYSDQWGHLSTFWSLLRTGRNRGNNSIGNSGSPNEPNTRPRPDTITYDPANDLPKYEDILKIRNAYAPPPYYCSNTNGNVNTTTTDAVTTNTTITSATTANATTTITTNANTNTSTTTSVISPLTTTNKDDTQINNASSNAHSSC |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000412758 | 1-313 | Tetraspanning orphan receptor | |||
Sequence: PQCESETNFHYDIPPGYKDDVLVDVNNMSPSLVSDTQKHERGSHEVKIKHFSPYIAVCVTTFSLAFCCFMVHAAITRQPTHLLPFFFIQVFDLIICLIHILGFMSSTSDIRLVIHTKTGPIYIKSTGLTFIILSISCMMLAFKAYCLGMVWDCYKYLMLNRRGNLLDDWYSDQWGHLSTFWSLLRTGRNRGNNSIGNSGSPNEPNTRPRPDTITYDPANDLPKYEDILKIRNAYAPPPYYCSNTNGNVNTTTTDAVTTNTTITSATTANATTTITTNANTNTSTTTSVISPLTTTNKDDTQINNASSNAHSSC |
Post-translational modification
Phosphorylated on tyrosine residues.
Keywords
- PTM
Expression
Developmental stage
Highly expressed in parasitic larvae (cercariae) and at a lower level in adults.
Interaction
Subunit
Interacts (via N-terminal extracellular domain) with human C2a.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 192-209 | Polar residues | ||||
Sequence: NNSIGNSGSPNEPNTRPR | ||||||
Region | 192-218 | Disordered | ||||
Sequence: NNSIGNSGSPNEPNTRPRPDTITYDPA | ||||||
Region | 279-313 | Disordered | ||||
Sequence: NTNTSTTTSVISPLTTTNKDDTQINNASSNAHSSC |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length313
- Mass (Da)34,846
- Last updated2011-09-21 v2
- Checksum60DA5651B27BEF1B
Sequence caution
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: P | ||||||
Compositional bias | 192-209 | Polar residues | ||||
Sequence: NNSIGNSGSPNEPNTRPR |