Q9BLM6 · TOR_SCHHA

Function

function

Cell surface receptor that binds to human complement C2a protein. This results in inhibition of the classical and lectin pathways of complement activation, probably due to interference with binding of C2a to C4b and interference with cleavage by C1 or MASP2 such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.

Miscellaneous

Specifically and strongly recognized by a serum from baboons vaccinated with irradiated parasite. Potential vaccine candidate molecule.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentlysosomal membrane
Cellular Componentplasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tetraspanning orphan receptor
  • Alternative names
    • Complement C2 receptor inhibitor tetraspanning
    • Complement C2 receptor inhibitor trispanning
    • Trispanning orphan receptor
      (Sh-TOR
      )

Gene names

    • Name
      TOR
    • Synonyms
      TM3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma

Accessions

  • Primary accession
    Q9BLM6

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Located on the surface tegumental plasma membrane, and tegumental surface pits of adult schistosomes so in contact with host blood plasma.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-54Extracellular
Transmembrane55-75Helical
Topological domain76-82Cytoplasmic
Transmembrane83-103Helical
Topological domain104-129Extracellular
Transmembrane130-150Helical
Topological domain151-313Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004127581-313Tetraspanning orphan receptor

Post-translational modification

Phosphorylated on tyrosine residues.

Keywords

Expression

Developmental stage

Highly expressed in parasitic larvae (cercariae) and at a lower level in adults.

Interaction

Subunit

Interacts (via N-terminal extracellular domain) with human C2a.

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias192-209Polar residues
Region192-218Disordered
Region279-313Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    313
  • Mass (Da)
    34,846
  • Last updated
    2011-09-21 v2
  • Checksum
    60DA5651B27BEF1B
PQCESETNFHYDIPPGYKDDVLVDVNNMSPSLVSDTQKHERGSHEVKIKHFSPYIAVCVTTFSLAFCCFMVHAAITRQPTHLLPFFFIQVFDLIICLIHILGFMSSTSDIRLVIHTKTGPIYIKSTGLTFIILSISCMMLAFKAYCLGMVWDCYKYLMLNRRGNLLDDWYSDQWGHLSTFWSLLRTGRNRGNNSIGNSGSPNEPNTRPRPDTITYDPANDLPKYEDILKIRNAYAPPPYYCSNTNGNVNTTTTDAVTTNTTITSATTANATTTITTNANTNTSTTTSVISPLTTTNKDDTQINNASSNAHSSC

Sequence caution

The sequence AAK11492.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias192-209Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U57714
EMBL· GenBank· DDBJ
AAK11492.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Similar Proteins

Disclaimer

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