Q9AEU0 · SECY2_STRGN
- ProteinAccessory Sec system protein translocase subunit SecY2
- GenesecY2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids407 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The central subunit of a protein translocation channel (Potential). Part of the accessory SecA2/SecY2 system specifically required to export GspB, a serine-rich repeat cell wall protein encoded upstream in the same operon.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | protein transmembrane transporter activity | |
Biological Process | SRP-dependent cotranslational protein targeting to membrane, translocation |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAccessory Sec system protein translocase subunit SecY2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionQ9AEU0
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 13-33 | Helical | ||||
Sequence: FLWTLLFVFIYVLGSKLTLPF | ||||||
Transmembrane | 65-85 | Helical | ||||
Sequence: FFSIGLAPWMSSILIWQMFTV | ||||||
Transmembrane | 104-124 | Helical | ||||
Sequence: MLLTLAIALIQSLGLVLNLPL | ||||||
Transmembrane | 133-153 | Helical | ||||
Sequence: GTIVFLDTLILIAGTYFLIWL | ||||||
Transmembrane | 158-178 | Helical | ||||
Sequence: SSMGLGGSIMIVMVSMISYIP | ||||||
Transmembrane | 192-212 | Helical | ||||
Sequence: PLILALIGFFSLCFLYLAVLV | ||||||
Transmembrane | 248-268 | Helical | ||||
Sequence: IMYAMTLVSIPQYFLMLLLFF | ||||||
Transmembrane | 287-307 | Helical | ||||
Sequence: IPWFILYLLTIFILAWAFAFI | ||||||
Transmembrane | 345-365 | Helical | ||||
Sequence: FAFVGALYLVLVAGLPMLLIF | ||||||
Transmembrane | 370-390 | Helical | ||||
Sequence: YMRLGMIPGMFMIFIGMVFSI |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Loss of adherence to human platelet cells, loss of export of cell wall protein GspB; GspB accumulates in the cytoplasm.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000414208 | 1-407 | Accessory Sec system protein translocase subunit SecY2 | |||
Sequence: MKSFFKPLILKKFLWTLLFVFIYVLGSKLTLPFVDVSSIAKLNGDSVTLNYAAALMGGNLRSMSFFSIGLAPWMSSILIWQMFTVSKRLGLNKLSMESQEKRRMLLTLAIALIQSLGLVLNLPLKTVAGVGQGTIVFLDTLILIAGTYFLIWLTDLNSSMGLGGSIMIVMVSMISYIPQDIWLSIQELKISPLILALIGFFSLCFLYLAVLVERAKYRIPINKINIHNRFKKYSYLDIRVNAAGGLPIMYAMTLVSIPQYFLMLLLFFQPNNRLLKEGILSLAMGGIPWFILYLLTIFILAWAFAFINVNSDQIAERMQRSGEYIENLYPGEATRRYIHKTVGYFAFVGALYLVLVAGLPMLLIFLDIRYMRLGMIPGMFMIFIGMVFSIKDEVDTLTLNDRYHSLF |
Interaction
Subunit
May form heterotrimers with SecE and SecG subunits (Potential). Component of the accessory SecA2/SecY2 protein translocase complex required to export cell wall protein GspB.
Structure
Sequence
- Sequence statusComplete
- Length407
- Mass (Da)46,158
- Last updated2001-06-01 v1
- Checksum9B516E14ADEE7E16