Q9A5I1 · DPO4_CAUVC

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site27Mg2+ (UniProtKB | ChEBI)
Site32Substrate discrimination
Binding site120Mg2+ (UniProtKB | ChEBI)
Active site121

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA repair
Biological ProcessDNA-templated DNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB
    • Ordered locus names
      CC_2466

Organism names

Accessions

  • Primary accession
    Q9A5I1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001739081-403DNA polymerase IV

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-203UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    403
  • Mass (Da)
    43,659
  • Last updated
    2002-08-02 v2
  • Checksum
    293F249AF0D9A7CF
MARCPACASPRTVFHEELGTLSIAHMDCDAFYASVEKRDDPSLRDLPVIIGGGKRGVVTTACYIARMSGAKSAMPMFKALKLCPDAVVIKPNFAKYKEESRRIHEKLDRLTPLIQPLSLDEAWIDLTGTERLHGATPAQMLARLQAEIERDIGLTVSVGLAPNKFLAKIASELDKPRGFSAIGAAEAQSFLANKPVNILPGVGPATVASLAEIGLRTVGDIAAADLKLLANRLGSGGMRLHRLAHGQDSRIVDPDQARKTISAETTFNDDLHKREDLEDELWPLCEKVAKQARQEGVAGRVATLKLRTPDFKIHTRRRTLAVPTQTARTLFQVARELLSAEPRGLAYRLIGAGLTEFVDADTAGADMFADEERRALKSETAIDALRGKFGAAAVVTGRALKGR

Sequence caution

The sequence AAK24437.1 differs from that shown. Reason: Erroneous initiation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE005673
EMBL· GenBank· DDBJ
AAK24437.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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