Q95WK4 · Q95WK4_ANOQU
- ProteinGlucose-6-phosphate 1-dehydrogenase
- GeneG6pd
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids153 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
Catalytic activity
- D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+This reaction proceeds in the forward direction.
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glucose-6-phosphate dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | glucose metabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphate 1-dehydrogenase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles
Accessions
- Primary accessionQ95WK4
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-152 | Glucose-6-phosphate dehydrogenase NAD-binding | ||||
Sequence: LWWLFRDNLVPSDTKFVGYARSKLSVAELKEKCRQYMKVKDAELEKFDEFWSVNFYVAGSYDSRRDFELLNQEIAKFEVGRAANRLFYLALPPSVFESVTVHIRNTCMGEKGWNRIIVEKPFGRDASSSNALSAHLSKLFSEDQLYRIDHYL |
Family and domain databases
Sequence
- Sequence statusFragment
- Length153
- Mass (Da)17,901
- Last updated2001-12-01 v1
- Checksum48F4D50B38AC19DD
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: L | ||||||
Non-terminal residue | 153 | |||||
Sequence: V |