Q92411 · TRPG_COCHE
- ProteinMultifunctional tryptophan biosynthesis protein
- GeneTRP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids768 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
Catalytic activity
- N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | anthranilate synthase activity | |
Molecular Function | indole-3-glycerol-phosphate synthase activity | |
Molecular Function | phosphoribosylanthranilate isomerase activity | |
Biological Process | glutamine metabolic process | |
Biological Process | tryptophan biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional tryptophan biosynthesis protein
Including 3 domains:
- Recommended nameAnthranilate synthase component 2
- EC number
- Short namesAS
- Alternative names
- Recommended nameIndole-3-glycerol phosphate synthase
- EC number
- Short namesIGPS
- Recommended nameN-(5'-phosphoribosyl)anthranilate isomerase
- EC number
- Short namesPRAI
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Bipolaris
Accessions
- Primary accessionQ92411
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000056856 | 1-768 | Multifunctional tryptophan biosynthesis protein | |||
Sequence: MPSSTLIDHSPRNPNPSPPRITASNVILIDNYDSFTWNVYQYLVFEGAFVTVYRNDEITLDELIAKKPTQLVISQVPDTRKEDVALAIEPLRTSVAKSPFSACAWESCIFYSYGGTVDVTGQILHGKTCPLKHDGKGVFAGVPQDVPVTRYHSLAGTHGTLPDCLEISATIPANADAEIKEVIMGVRHKEYVIEGVQFHPESILTEHGRLMMRNFLKMQGGTWAENERLQKEAHAQAIGAAFSESAMVQRTDSRTHLQKIYDHRRAAVAEQKKIPSNRPVDLQAAYDSNLAPPQINFPERLRQSPFKLSLMSEIKRASPSKGIISLSTCAPAQARLYAKAGARPISVLTEPEWFKGSIEDLRAVRQSIEGMANRPALLRKEFIFDEYQILEGRLAGADTVLVIVKMLETELLERLLGLSDSVGMEPLVEVQNTDEMKIAVKLGAQVIGVNNRNLVNFEVDIGTTNRLIQMVPKETILCALSGIAGPKDVEAYIKDGVGAVLVGEALMRASDMSQFISELLGGPYKEVRASSSSPIVKISGTRSEAAVAAVEAGADLIGIILAPGLKRTVTAETALSISEAVHKTKKPNVSKSGLLADSKTASDFFDHGASRLLETISRALLVGVFRNQSLEYVLEQQRLLNLDVVQLHGQEPIEWAKLVPVPVLKAFNPQDHGIGTRGYHALPLLDAGSGGSGKQLGLSDVKAAFTKDDGIKIILGRGLEPDNVQTTLAGLDEYRDRVYAVDVSSGVEEDGQQSLDKIRSFVKAAKSL |
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-225 | Glutamine amidotransferase type-1 | ||||
Sequence: NVILIDNYDSFTWNVYQYLVFEGAFVTVYRNDEITLDELIAKKPTQLVISQVPDTRKEDVALAIEPLRTSVAKSPFSACAWESCIFYSYGGTVDVTGQILHGKTCPLKHDGKGVFAGVPQDVPVTRYHSLAGTHGTLPDCLEISATIPANADAEIKEVIMGVRHKEYVIEGVQFHPESILTEHGRLMMRNFLKMQGGTWAE | ||||||
Region | 256-520 | Indole-3-glycerol phosphate synthase | ||||
Sequence: HLQKIYDHRRAAVAEQKKIPSNRPVDLQAAYDSNLAPPQINFPERLRQSPFKLSLMSEIKRASPSKGIISLSTCAPAQARLYAKAGARPISVLTEPEWFKGSIEDLRAVRQSIEGMANRPALLRKEFIFDEYQILEGRLAGADTVLVIVKMLETELLERLLGLSDSVGMEPLVEVQNTDEMKIAVKLGAQVIGVNNRNLVNFEVDIGTTNRLIQMVPKETILCALSGIAGPKDVEAYIKDGVGAVLVGEALMRASDMSQFISELL | ||||||
Region | 535-768 | N-(5'-phosphoribosyl)anthranilate isomerase | ||||
Sequence: IVKISGTRSEAAVAAVEAGADLIGIILAPGLKRTVTAETALSISEAVHKTKKPNVSKSGLLADSKTASDFFDHGASRLLETISRALLVGVFRNQSLEYVLEQQRLLNLDVVQLHGQEPIEWAKLVPVPVLKAFNPQDHGIGTRGYHALPLLDAGSGGSGKQLGLSDVKAAFTKDDGIKIILGRGLEPDNVQTTLAGLDEYRDRVYAVDVSSGVEEDGQQSLDKIRSFVKAAKSL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length768
- Mass (Da)83,655
- Last updated1997-02-01 v1
- ChecksumB2F215AA304B8B00