Q92411 · TRPG_COCHE

Function

function

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site76-78L-glutamine (UniProtKB | ChEBI)
Active site103Nucleophile; for GATase activity
Binding site153-154L-glutamine (UniProtKB | ChEBI)
Active site199For GATase activity
Active site201For GATase activity

GO annotations

AspectTerm
Molecular Functionanthranilate synthase activity
Molecular Functionindole-3-glycerol-phosphate synthase activity
Molecular Functionphosphoribosylanthranilate isomerase activity
Biological Processglutamine metabolic process
Biological Processtryptophan biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00035UER00040
    • UPA00035UER00042
    • UPA00035UER00043

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional tryptophan biosynthesis protein

Including 3 domains:

  • Recommended name
    Anthranilate synthase component 2
  • EC number
  • Short names
    AS
  • Alternative names
    • Anthranilate synthase, glutamine amidotransferase component
  • Recommended name
    Indole-3-glycerol phosphate synthase
  • EC number
  • Short names
    IGPS
  • Recommended name
    N-(5'-phosphoribosyl)anthranilate isomerase
  • EC number
  • Short names
    PRAI

Gene names

    • Name
      TRP1

Organism names

Accessions

  • Primary accession
    Q92411

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000568561-768Multifunctional tryptophan biosynthesis protein

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain25-225Glutamine amidotransferase type-1
Region256-520Indole-3-glycerol phosphate synthase
Region535-768N-(5'-phosphoribosyl)anthranilate isomerase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    768
  • Mass (Da)
    83,655
  • Last updated
    1997-02-01 v1
  • Checksum
    B2F215AA304B8B00
MPSSTLIDHSPRNPNPSPPRITASNVILIDNYDSFTWNVYQYLVFEGAFVTVYRNDEITLDELIAKKPTQLVISQVPDTRKEDVALAIEPLRTSVAKSPFSACAWESCIFYSYGGTVDVTGQILHGKTCPLKHDGKGVFAGVPQDVPVTRYHSLAGTHGTLPDCLEISATIPANADAEIKEVIMGVRHKEYVIEGVQFHPESILTEHGRLMMRNFLKMQGGTWAENERLQKEAHAQAIGAAFSESAMVQRTDSRTHLQKIYDHRRAAVAEQKKIPSNRPVDLQAAYDSNLAPPQINFPERLRQSPFKLSLMSEIKRASPSKGIISLSTCAPAQARLYAKAGARPISVLTEPEWFKGSIEDLRAVRQSIEGMANRPALLRKEFIFDEYQILEGRLAGADTVLVIVKMLETELLERLLGLSDSVGMEPLVEVQNTDEMKIAVKLGAQVIGVNNRNLVNFEVDIGTTNRLIQMVPKETILCALSGIAGPKDVEAYIKDGVGAVLVGEALMRASDMSQFISELLGGPYKEVRASSSSPIVKISGTRSEAAVAAVEAGADLIGIILAPGLKRTVTAETALSISEAVHKTKKPNVSKSGLLADSKTASDFFDHGASRLLETISRALLVGVFRNQSLEYVLEQQRLLNLDVVQLHGQEPIEWAKLVPVPVLKAFNPQDHGIGTRGYHALPLLDAGSGGSGKQLGLSDVKAAFTKDDGIKIILGRGLEPDNVQTTLAGLDEYRDRVYAVDVSSGVEEDGQQSLDKIRSFVKAAKSL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X70035
EMBL· GenBank· DDBJ
CAA49629.1
EMBL· GenBank· DDBJ
Genomic DNA

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