Q90341 · MYC1_CYPCA
- ProteinTranscriptional regulator Myc-1
- Genemyca
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids394 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | protein dimerization activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTranscriptional regulator Myc-1
- Short namesc-Myc-1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Cyprinus
Accessions
- Primary accessionQ90341
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000127316 | 1-394 | Transcriptional regulator Myc-1 | |||
Sequence: MPVSASLAYKNYDYDYDSIQPYFYFDNDDEDFYHHQQGQTQPPAPSEDIWKKFELLPTPPLSPSRRQSLSTAEQLEMVSEFLGDDVVNQSFICDADYSQSFIKSIIIQDCMWSGFSAAAKLEKVVSERLASLHAARKELMSDSSSNRLNASYLQDVSTSASECIDPSVVFPYPLPESGKSSKVAPSEPMPVLDTPPNSSSSSGSDSEEEEEEEEEEEEEEEEEEIDVVTVEKRQKKNETAVSDSRYPSPLVLKRCHVSTHQHNYAAHPSTRHDQPAVKRLRLEASSNSNSRHVKQRKCTSPRTSDSEDNDKRRTHNVLERQRRNELKLSFFALRDEIPDVANNEKAAKVVILKKATECIHSMQLDEQRLLSIKEQLRRKSEQLKHRLQLLRSSH | ||||||
Glycosylation | 58 | O-linked (GlcNAc) threonine | ||||
Sequence: T |
Keywords
- PTM
PTM databases
Interaction
Subunit
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).
Structure
Family & Domains
Features
Showing features for motif, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 76-84 | 9aaTAD | ||||
Sequence: EMVSEFLGD | ||||||
Region | 177-247 | Disordered | ||||
Sequence: SGKSSKVAPSEPMPVLDTPPNSSSSSGSDSEEEEEEEEEEEEEEEEEEIDVVTVEKRQKKNETAVSDSRYP | ||||||
Compositional bias | 204-226 | Acidic residues | ||||
Sequence: SDSEEEEEEEEEEEEEEEEEEID | ||||||
Region | 283-318 | Disordered | ||||
Sequence: EASSNSNSRHVKQRKCTSPRTSDSEDNDKRRTHNVL | ||||||
Compositional bias | 298-318 | Basic and acidic residues | ||||
Sequence: CTSPRTSDSEDNDKRRTHNVL | ||||||
Domain | 310-362 | bHLH | ||||
Sequence: DKRRTHNVLERQRRNELKLSFFALRDEIPDVANNEKAAKVVILKKATECIHSM | ||||||
Region | 369-390 | Leucine-zipper | ||||
Sequence: LLSIKEQLRRKSEQLKHRLQLL |
Domain
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Family and domain databases
Sequence
- Sequence statusComplete
- Length394
- Mass (Da)44,996
- Last updated1996-11-01 v1
- Checksum7146C81C920D71D0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 204-226 | Acidic residues | ||||
Sequence: SDSEEEEEEEEEEEEEEEEEEID | ||||||
Compositional bias | 298-318 | Basic and acidic residues | ||||
Sequence: CTSPRTSDSEDNDKRRTHNVL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D37887 EMBL· GenBank· DDBJ | BAA07129.1 EMBL· GenBank· DDBJ | Genomic DNA |