Q8ZWP5 · G1PDH_PYRAE
- ProteinGlycerol-1-phosphate dehydrogenase [NAD(P)+]
- GeneegsA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids342 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
Catalytic activity
- NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Membrane lipid metabolism; glycerophospholipid metabolism.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 84-88 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GRPID | ||||||
Binding site | 106-109 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TAAS | ||||||
Binding site | 111 | substrate | ||||
Sequence: D | ||||||
Binding site | 115 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 160 | substrate | ||||
Sequence: D | ||||||
Binding site | 160 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 241 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 245 | substrate | ||||
Sequence: H | ||||||
Binding site | 260 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | glycerol-1-phosphate dehydrogenase (NAD+) activity | |
Molecular Function | glycerol-1-phosphate dehydrogenase (NADP+) activity | |
Molecular Function | metal ion binding | |
Biological Process | glycerophospholipid metabolic process | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol-1-phosphate dehydrogenase [NAD(P)+]
- EC number
- Short namesG1P dehydrogenase ; G1PDH
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Thermoproteales > Thermoproteaceae > Pyrobaculum
Accessions
- Primary accessionQ8ZWP5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000157348 | 1-342 | Glycerol-1-phosphate dehydrogenase [NAD(P)+] | |||
Sequence: MKQLESFQIPRIVIFGPGAILKTPLVVSELKAGRILVISGKSATTAYANQVAQLLSNYSVDVVRYNEVDLSKSSYDLVIGVGGGRPIDMAKVYSCVHKKPLVVIPTAASHDGIASPYVSYTLSQKLQTYGKIVASPVAIIADTSVILSAPSRLLKAGIGDLLGKIIAVRDWQLAHRLKGEEYSEYAAHLAVTSYKIAATNARRIRNFTREEDVRVLVKALIGCGVAMGIAGSSRPCSGSEHLFAHAIELRLQEESSEAVHGELVALGTIIMAYLHGINWRRIKKIAEIVGLPTTLKQAGIDADMAVEALTTAHALRPDRYTILGNGLSREAARRALEDTELI |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length342
- Mass (Da)36,878
- Last updated2002-03-01 v1
- Checksum5E6811B6CCD133DB
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE009441 EMBL· GenBank· DDBJ | AAL63655.1 EMBL· GenBank· DDBJ | Genomic DNA |