Q8ZWP5 · G1PDH_PYRAE

Function

function

Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site84-88NAD+ (UniProtKB | ChEBI)
Binding site106-109NAD+ (UniProtKB | ChEBI)
Binding site111substrate
Binding site115NAD+ (UniProtKB | ChEBI)
Binding site160substrate
Binding site160Zn2+ (UniProtKB | ChEBI); catalytic
Binding site241Zn2+ (UniProtKB | ChEBI); catalytic
Binding site245substrate
Binding site260Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglycerol-1-phosphate dehydrogenase (NAD+) activity
Molecular Functionglycerol-1-phosphate dehydrogenase (NADP+) activity
Molecular Functionmetal ion binding
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-1-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Short names
    G1P dehydrogenase
    ; G1PDH
  • Alternative names
    • Enantiomeric glycerophosphate synthase
    • sn-glycerol-1-phosphate dehydrogenase

Gene names

    • Name
      egsA
    • Ordered locus names
      PAE1685

Organism names

Accessions

  • Primary accession
    Q8ZWP5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001573481-342Glycerol-1-phosphate dehydrogenase [NAD(P)+]

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the glycerol-1-phosphate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    342
  • Mass (Da)
    36,878
  • Last updated
    2002-03-01 v1
  • Checksum
    5E6811B6CCD133DB
MKQLESFQIPRIVIFGPGAILKTPLVVSELKAGRILVISGKSATTAYANQVAQLLSNYSVDVVRYNEVDLSKSSYDLVIGVGGGRPIDMAKVYSCVHKKPLVVIPTAASHDGIASPYVSYTLSQKLQTYGKIVASPVAIIADTSVILSAPSRLLKAGIGDLLGKIIAVRDWQLAHRLKGEEYSEYAAHLAVTSYKIAATNARRIRNFTREEDVRVLVKALIGCGVAMGIAGSSRPCSGSEHLFAHAIELRLQEESSEAVHGELVALGTIIMAYLHGINWRRIKKIAEIVGLPTTLKQAGIDADMAVEALTTAHALRPDRYTILGNGLSREAARRALEDTELI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE009441
EMBL· GenBank· DDBJ
AAL63655.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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