Q8W9N5 · NU2M_DUGDU

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial respiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone
Biological Processmitochondrial respiratory chain complex I assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 2
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 2

Gene names

    • Name
      MT-ND2
    • Synonyms
      MTND2, NADH2, ND2

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q8W9N5

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-46Helical
Transmembrane60-80Helical
Transmembrane96-116Helical
Transmembrane123-143Helical
Transmembrane151-171Helical
Transmembrane178-198Helical
Transmembrane200-220Helical
Transmembrane240-260Helical
Transmembrane274-294Helical
Transmembrane325-345Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001175851-347NADH-ubiquinone oxidoreductase chain 2

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    38,785
  • Last updated
    2002-03-01 v1
  • Checksum
    B90D86FB062FA5CB
MNPLILSMILTTLAMGTMATMLSSNWLLAWMGLEMNMLAMIPILTMNPNPRSTEAATKYFLTQATASMLLMMAIMINFMLSGQWSITKLPNTTVSSMALAALMMKLGLAPFHFWVPEVTQGTSLTSGMILLTWQKLAPLSILYQIDTSVDITILTVSGLLSILVGGWGGLNQTQLRKILAYSSIAHMGWMLIIMPYNPSLTILNLLIYILMTLSIFMIMMNNHSTSTLTLALLWNKAPMMMILLTITLLSLGGLPPLSGFMPKWLIIHELTKNDSIILPMSMAMFALLNLYFYMRLIYSSSLTMFPSTNNMKMKWHFTNRSHLTLLPPLIILSTLTLPLTPFLSILE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ421723
EMBL· GenBank· DDBJ
CAD18909.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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