Q8VS53 · PYRH_LIMRT
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids240 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- UMP + ATP = UDP + ADP
Activity regulation
Allosterically activated by GTP. Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12-15 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KLSG | ||||||
Binding site | 54 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 55 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 59 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 74 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 135-142 | UMP (UniProtKB | ChEBI) | ||||
Sequence: TGSPYFST | ||||||
Binding site | 163 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 169 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 172 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Limosilactobacillus
Accessions
- Primary accessionQ8VS53
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000143852 | 1-240 | Uridylate kinase | |||
Sequence: MSDIKYNRVILKLSGEALAGEKGFGINPPVLKDVAKELKEVHELGVQIAIVVGGGNMWRGVTGAELGMERAQADYIGMLATIMNALSLQDALESLDVPTRVQTSIEMRQIAEPYIRRKAIRHLEKDRIVIFAGGTGSPYFSTDTTAALRAAEINADAILMGKNGVDGVYNADPNKDASAVKFDHLTHMDLIEKNLHVMDTTASSLSMDNHIPLVVFNLNTPGNIMKVVKGQEVGTTIEGD |
Interaction
Subunit
Homohexamer.
Structure
Sequence
- Sequence statusComplete
- Length240
- Mass (Da)25,958
- Last updated2002-03-01 v1
- Checksum32D354CAF5671B65