Q8VS53 · PYRH_LIMRT

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Catalytic activity

Activity regulation

Allosterically activated by GTP. Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

124020406080100120140160180200220240
TypeIDPosition(s)Description
Binding site12-15ATP (UniProtKB | ChEBI)
Binding site54UMP (UniProtKB | ChEBI)
Binding site55ATP (UniProtKB | ChEBI)
Binding site59ATP (UniProtKB | ChEBI)
Binding site74UMP (UniProtKB | ChEBI)
Binding site135-142UMP (UniProtKB | ChEBI)
Binding site163ATP (UniProtKB | ChEBI)
Binding site169ATP (UniProtKB | ChEBI)
Binding site172ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH

Organism names

Accessions

  • Primary accession
    Q8VS53

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001438521-240Uridylate kinase

Interaction

Subunit

Homohexamer.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region20-25Involved in allosteric activation by GTP

Sequence similarities

Belongs to the UMP kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    240
  • Mass (Da)
    25,958
  • Last updated
    2002-03-01 v1
  • Checksum
    32D354CAF5671B65
MSDIKYNRVILKLSGEALAGEKGFGINPPVLKDVAKELKEVHELGVQIAIVVGGGNMWRGVTGAELGMERAQADYIGMLATIMNALSLQDALESLDVPTRVQTSIEMRQIAEPYIRRKAIRHLEKDRIVIFAGGTGSPYFSTDTTAALRAAEINADAILMGKNGVDGVYNADPNKDASAVKFDHLTHMDLIEKNLHVMDTTASSLSMDNHIPLVVFNLNTPGNIMKVVKGQEVGTTIEGD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF401482
EMBL· GenBank· DDBJ
AAL60143.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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