Q8VS50 · MSRA_XANCH
- ProteinPeptide methionine sulfoxide reductase MsrA
- GenemsrA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids216 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Catalytic activity
- [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 + RHEA-COMP:12313 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ RHEA-COMP:12315
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 54 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity | |
Molecular Function | peptide-methionine (S)-S-oxide reductase activity | |
Biological Process | protein modification process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide methionine sulfoxide reductase MsrA
- EC number
- Short namesProtein-methionine-S-oxide reductase
- Alternative names
Gene names
Organism names
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionQ8VS50
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000138611 | 1-216 | Peptide methionine sulfoxide reductase MsrA | |||
Sequence: MLGIGAFKQRMPRPGEALPGREQALPLHNTHLVNGHPLRGEFTGLAQVQFGLGCFWGAERKFWNVPGVYTTAVGYAGGQTPNATYSEVCSGQTGHTEAVLVVFDEQAVSFAQLLRTFWESHDPTQGMQQGNDVGTQYRSAIYCTTQAQYDAALASRDAYQQQLTASGYGDITTEIRFPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA |
Structure
Sequence
- Sequence statusComplete
- Length216
- Mass (Da)23,464
- Last updated2002-03-01 v1
- ChecksumEE16DC69DA867ED8