Q8U1G7 · UPP_PYRFU

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site38-42GTP (UniProtKB | ChEBI)
Binding site875-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1125-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site140-1485-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site204uracil (UniProtKB | ChEBI)
Binding site209-211uracil (UniProtKB | ChEBI)
Binding site2105-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • Ordered locus names
      PF1241

Organism names

Accessions

  • Primary accession
    Q8U1G7

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001209241-232Uracil phosphoribosyltransferase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    232
  • Mass (Da)
    26,164
  • Last updated
    2002-06-01 v1
  • Checksum
    CE7E6ADD397A42E0
MIEDKRWGGVYSFEDSPYIMEILTELRDKDTDSIKFRKGLVKLGRYMGYEITKTMDVEKVKVETPLEETEGIIVKDRRNVVIITVLRAAIPFMEGLIKVFEHARVGIVSAARGKPPKFEIEMNYIKIPQITPEDTVIVADPMIATGSTLLRVLEEVKKYGTPKRTLVVGVLAAPEGITRIKEKFPEVEIFVAKIDRELNDKGYILPGLGDAGDRAFGEPVKITTLPQVHYIE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE009950
EMBL· GenBank· DDBJ
AAL81365.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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