Q8TAE8 · G45IP_HUMAN

  • Protein
    Large ribosomal subunit protein mL64
  • Gene
    GADD45GIP1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

Miscellaneous

Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial large ribosomal subunit
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Cellular Componentnucleoplasm
Biological Processmitochondrial translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Large ribosomal subunit protein mL64
  • Alternative names
    • 39S ribosomal protein L59, mitochondrial (MRP-L59)
    • CKII beta-associating protein
    • CR6-interacting factor 1 (CRIF1)
    • Growth arrest and DNA damage-inducible proteins-interacting protein 1
    • Papillomavirus L2-interacting nuclear protein 1 (PLINP; PLINP-1)
    • p53-responsive gene 6 protein

Gene names

    • Name
      GADD45GIP1
    • Synonyms
      MRPL59, PLINP1, PRG6

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8TAE8
  • Secondary accessions
    • Q8IVM3
    • Q8TE51
    • Q969P9
    • Q9BSM6

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion
Nucleus
Note: Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659).
C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275).
This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275).

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 320 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002286201-222UniProtLarge ribosomal subunit protein mL64
Modified residue (large scale data)166PRIDEPhosphotyrosine
Modified residue (large scale data)221PRIDEPhosphoserine
Modified residue (large scale data)222PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.

Induction

Down-regulated by p53/TP53 in apoptotic cells.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605).
Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25278503, PubMed:25838379).
Interacts with GADD45A, GADD45B and GADD45G (PubMed:12716909).
Interacts with NR4A1 via the NR4A1 AB domain (PubMed:15459248).
Interacts with ATAD3A and ATAD3B (PubMed:22453275).
(Microbial infection) Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8TAE8ANKRD28 O150843EBI-372506, EBI-359567
BINARY Q8TAE8BPIFA1 Q9NP553EBI-372506, EBI-953896
BINARY Q8TAE8CADPS A2RRN73EBI-372506, EBI-10179719
BINARY Q8TAE8CARD10 Q9BWT73EBI-372506, EBI-3866279
BINARY Q8TAE8CBY2 Q8NA61-23EBI-372506, EBI-11524851
BINARY Q8TAE8CCNC P248633EBI-372506, EBI-395261
BINARY Q8TAE8CEP70 Q8NHQ13EBI-372506, EBI-739624
BINARY Q8TAE8DVL3 Q929973EBI-372506, EBI-739789
BINARY Q8TAE8EAF1 Q96JC93EBI-372506, EBI-769261
BINARY Q8TAE8ENKD1 Q9H0I23EBI-372506, EBI-744099
BINARY Q8TAE8GADD45A P245223EBI-372506, EBI-448167
XENO Q8TAE8Gadd45b P223393EBI-372506, EBI-2266938
BINARY Q8TAE8GADD45G O952574EBI-372506, EBI-448202
BINARY Q8TAE8GAS8 O959953EBI-372506, EBI-1052570
BINARY Q8TAE8GEM P550403EBI-372506, EBI-744104
BINARY Q8TAE8GOLGA2 Q083793EBI-372506, EBI-618309
BINARY Q8TAE8GOLGA6A Q9NYA33EBI-372506, EBI-11163335
BINARY Q8TAE8GOLGA6L9 A6NEM13EBI-372506, EBI-5916454
BINARY Q8TAE8GPRASP2 Q96D093EBI-372506, EBI-473189
BINARY Q8TAE8HMG20A Q9NP663EBI-372506, EBI-740641
BINARY Q8TAE8KANK2 Q63ZY33EBI-372506, EBI-2556193
BINARY Q8TAE8KIFC3 Q9BVG8-53EBI-372506, EBI-14069005
BINARY Q8TAE8KRT27 Q7Z3Y83EBI-372506, EBI-3044087
BINARY Q8TAE8KRT31 Q153233EBI-372506, EBI-948001
BINARY Q8TAE8KRT34 O760113EBI-372506, EBI-1047093
BINARY Q8TAE8KRT40 Q6A1623EBI-372506, EBI-10171697
BINARY Q8TAE8LDOC1 O957513EBI-372506, EBI-740738
BINARY Q8TAE8LRRC73 Q5JTD73EBI-372506, EBI-12003882
BINARY Q8TAE8LZTS2 Q9BRK43EBI-372506, EBI-741037
BINARY Q8TAE8MAGEA11 P433643EBI-372506, EBI-739552
BINARY Q8TAE8MAGEA6 P433603EBI-372506, EBI-1045155
BINARY Q8TAE8MBD3 O95983-23EBI-372506, EBI-11978579
BINARY Q8TAE8MIPOL1 Q8TD103EBI-372506, EBI-2548751
BINARY Q8TAE8MKRN3 Q130643EBI-372506, EBI-2340269
BINARY Q8TAE8MRPL38 Q96DV45EBI-372506, EBI-720441
BINARY Q8TAE8MTUS2 Q5JR59-33EBI-372506, EBI-11522433
BINARY Q8TAE8MYG1 Q9HB073EBI-372506, EBI-709754
BINARY Q8TAE8MYO15B Q96JP23EBI-372506, EBI-7950783
BINARY Q8TAE8NFKBID Q8NI383EBI-372506, EBI-10271199
BINARY Q8TAE8NTAQ1 Q96HA83EBI-372506, EBI-741158
BINARY Q8TAE8OIP5 O434823EBI-372506, EBI-536879
BINARY Q8TAE8PBX4 Q9BYU13EBI-372506, EBI-10302990
BINARY Q8TAE8PICK1 Q9NRD53EBI-372506, EBI-79165
BINARY Q8TAE8PNMA1 Q8ND903EBI-372506, EBI-302345
BINARY Q8TAE8PRDM6 Q9NQX03EBI-372506, EBI-11320284
BINARY Q8TAE8PSMB1 P206183EBI-372506, EBI-372273
BINARY Q8TAE8RBM11 P570523EBI-372506, EBI-741332
BINARY Q8TAE8SPTA1 P025493EBI-372506, EBI-375617
BINARY Q8TAE8STAT3 P407634EBI-372506, EBI-518675
XENO Q8TAE8Stat3 P422273EBI-372506, EBI-602878
BINARY Q8TAE8TFIP11 Q9UBB93EBI-372506, EBI-1105213
BINARY Q8TAE8TRAF1 Q130773EBI-372506, EBI-359224
BINARY Q8TAE8TRIM27 P143733EBI-372506, EBI-719493
BINARY Q8TAE8WWP2 O003083EBI-372506, EBI-743923
BINARY Q8TAE8ZRANB1 Q9UGI03EBI-372506, EBI-527853
View interactors in UniProtKB
View CPX-5226 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, coiled coil, motif.

TypeIDPosition(s)Description
Region19-46Disordered
Coiled coil99-212
Motif184-200Nuclear localization signal
Region188-222Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    222
  • Mass (Da)
    25,384
  • Last updated
    2002-06-01 v1
  • Checksum
    304C397AEC958804
MAASVRQARSLLGVAATLAPGSRGYRARPPPRRRPGPRWPDPEDLLTPRWQLGPRYAAKQFARYGAASGVVPGSLWPSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQHIAECMAKMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQELLQDLEKKERKRLKEEKQKRKKEARAAALAAAVAQDPAASGAPSS

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict7-10in Ref. 1; CAD22344

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ429498
EMBL· GenBank· DDBJ
CAD22344.1
EMBL· GenBank· DDBJ
mRNA
AF479749
EMBL· GenBank· DDBJ
AAL85877.1
EMBL· GenBank· DDBJ
mRNA
AF475095
EMBL· GenBank· DDBJ
AAM10639.1
EMBL· GenBank· DDBJ
mRNA
BC004944
EMBL· GenBank· DDBJ
AAH04944.1
EMBL· GenBank· DDBJ
mRNA
BC013039
EMBL· GenBank· DDBJ
AAH13039.2
EMBL· GenBank· DDBJ
mRNA
BC013027
EMBL· GenBank· DDBJ
AAH13027.2
EMBL· GenBank· DDBJ
mRNA
BC069200
EMBL· GenBank· DDBJ
AAH69200.1
EMBL· GenBank· DDBJ
mRNA
AJ295986
EMBL· GenBank· DDBJ
CAC82499.1
EMBL· GenBank· DDBJ
mRNA
AF147080
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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