Q8PLG5 · HIS2_XANAC
- ProteinHistidine biosynthesis bifunctional protein HisIE
- GenehisI
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids206 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H+
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | phosphoribosyl-AMP cyclohydrolase activity | |
Molecular Function | phosphoribosyl-ATP diphosphatase activity | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidine biosynthesis bifunctional protein HisIE
Including 2 domains:
- Recommended namePhosphoribosyl-AMP cyclohydrolase
- EC number
- Short namesPRA-CH
- Recommended namePhosphoribosyl-ATP pyrophosphatase
- EC number
- Short namesPRA-PH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionQ8PLG5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000136450 | 1-206 | Histidine biosynthesis bifunctional protein HisIE | |||
Sequence: MGSNEVATGDPLATLDWNKGEGLLPVIVQDADNLRVLMLGYMNAQALAVTQQRGEVTFFSRSKQRLWTKGESSGNVLRVVSIQTDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGSLDALVAERERERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQDDDALLGESADLLYHLIVLLRARGLGLGDAAALLESRHQ |
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-117 | Phosphoribosyl-AMP cyclohydrolase | ||||
Sequence: MGSNEVATGDPLATLDWNKGEGLLPVIVQDADNLRVLMLGYMNAQALAVTQQRGEVTFFSRSKQRLWTKGESSGNVLRVVSIQTDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQF | ||||||
Region | 118-206 | Phosphoribosyl-ATP pyrophosphohydrolase | ||||
Sequence: LGSLDALVAERERERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQDDDALLGESADLLYHLIVLLRARGLGLGDAAALLESRHQ |
Sequence similarities
In the N-terminal section; belongs to the PRA-CH family.
In the C-terminal section; belongs to the PRA-PH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length206
- Mass (Da)22,262
- Last updated2002-10-01 v1
- Checksum1B04984CEEFBD377
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE008923 EMBL· GenBank· DDBJ | AAM36697.1 EMBL· GenBank· DDBJ | Genomic DNA |