Q8N983 · RM43_HUMAN

  • Protein
    Large ribosomal subunit protein mL43
  • Gene
    MRPL43
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial large ribosomal subunit
Cellular Componentmitochondrial ribosome
Cellular Componentmitochondrion
Molecular FunctionRNA binding
Molecular Functionstructural constituent of ribosome
Biological Processmitochondrial translation
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Large ribosomal subunit protein mL43
  • Alternative names
    • 39S ribosomal protein L43, mitochondrial (L43mt; MRP-L43)
    • Mitochondrial ribosomal protein bMRP36a

Gene names

    • Name
      MRPL43

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8N983
  • Secondary accessions
    • B1AL06
    • B1AL07
    • B1AL09
    • B1AL10
    • C9J5Q3

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 283 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, transit peptide, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_0000030561?-215UniProtLarge ribosomal subunit protein mL43
Transit peptide1-?UniProtMitochondrion
Modified residue (large scale data)93PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Tissue specificity

High relative levels in skeletal muscle and testis. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with TWNK.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605).
Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins

Binary interactions

Complex viewer

View interactors in UniProtKB
View CPX-5226 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (6)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 6 isoforms produced by Alternative splicing.

Q8N983-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    215
  • Mass (Da)
    23,431
  • Last updated
    2002-10-01 v1
  • Checksum
    059C6E36FEB0D235
MTARGTPSRFLASVLHNGLGRYVQQLQRLSFSVSRDGASSRGAREFVEREVIDFARRNPGVVIYVNSRPCCVPRVVAEYLNGAVREESIHCKSVEEISTLVQKLADQSGLDVIRIRKPFHTDNPSIQGQWHPFTNKPTTFRGLRPREVQDPAPAQDTGLRLSAVAPQILLPGWPDPPDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA

Q8N983-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 177-215: PDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA → ISVQSSDLPWGNTHYRPEPLSSTTWL

Q8N983-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8N983-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8N983-6

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 157-215: TGLRLSAVAPQILLPGWPDPPDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA → AAEFLGEGAGPCWYSIVALPQKHIAIAIHPPQPAGQCHQAIGHWPETVCSCTADPPARLARPNISSVIRSSLGKYPLPS

Q8N983-7

  • Name
    6
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 157-215: TGLRLSAVAPQILLPGWPDPPDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA → AAEFLGEGAGPCWYSIVALPQKHIAIAIHPPQPAGQCHQAIGHWPETVCSCTADPPARLARPTRPPHSGSYLILIDLCSSPYAVRSFLPPDCPCTDHCVLSVKAA

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YBU8H0YBU8_HUMANMRPL43148
H0Y6Y8H0Y6Y8_HUMANMRPL43169
M0R051M0R051_HUMANMRPL4344
B1AL05B1AL05_HUMANMRPL43184

Sequence caution

The sequence BAB40861.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_011029156-159in isoform 4
Alternative sequenceVSP_011027156-164in isoform 3
Alternative sequenceVSP_054092157-215in isoform 5
Alternative sequenceVSP_054093157-215in isoform 6
Alternative sequenceVSP_011030160-215in isoform 4
Alternative sequenceVSP_011028165-215in isoform 3
Alternative sequenceVSP_011026177-215in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB049656
EMBL· GenBank· DDBJ
BAB40861.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK095556
EMBL· GenBank· DDBJ
BAC04572.1
EMBL· GenBank· DDBJ
mRNA
AK300237
EMBL· GenBank· DDBJ
BAG62005.1
EMBL· GenBank· DDBJ
mRNA
AL133215
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471066
EMBL· GenBank· DDBJ
EAW49795.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471066
EMBL· GenBank· DDBJ
EAW49796.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471066
EMBL· GenBank· DDBJ
EAW49797.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471066
EMBL· GenBank· DDBJ
EAW49799.1
EMBL· GenBank· DDBJ
Genomic DNA
BC015905
EMBL· GenBank· DDBJ
AAH15905.1
EMBL· GenBank· DDBJ
mRNA
BC041165
EMBL· GenBank· DDBJ
AAH41165.1
EMBL· GenBank· DDBJ
mRNA
BC052639
EMBL· GenBank· DDBJ
AAH52639.1
EMBL· GenBank· DDBJ
mRNA
BC053373
EMBL· GenBank· DDBJ
AAH53373.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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