Q8MKA5 · Q8MKA5_AMBHO
- ProteinBeta-2 adrenergic receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids275 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | early endosome | |
Cellular Component | Golgi apparatus | |
Cellular Component | plasma membrane | |
Molecular Function | beta2-adrenergic receptor activity | |
Molecular Function | norepinephrine binding | |
Biological Process | adenylate cyclase-activating adrenergic receptor signaling pathway | |
Biological Process | negative regulation of smooth muscle contraction | |
Biological Process | norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameBeta-2 adrenergic receptor
- Short namesBeta-2 adrenoceptor
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Afrotheria > Chrysochloridae > Amblysominae > Amblysomus
Accessions
- Primary accessionQ8MKA5
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 19-45 | Helical | ||||
Sequence: YFITSLACADLVMGLAVVPFGASHILM | ||||||
Transmembrane | 57-78 | Helical | ||||
Sequence: FWTSIDVLCVTASIETLCVIAV | ||||||
Transmembrane | 99-118 | Helical | ||||
Sequence: ARVVILMVWIVSGLTSFLPI | ||||||
Transmembrane | 147-168 | Helical | ||||
Sequence: AYAIASSVVSFYLPLVVMVFVY | ||||||
Transmembrane | 224-244 | Helical | ||||
Sequence: LGIIMGTFTLCWLPFFIVNIV |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Binds NHERF1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC. Interacts with USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4. Interacts with MARCHF2.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-275 | G-protein coupled receptors family 1 profile | ||||
Sequence: VLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHDAAINCYAEETCCDFFTNRAYAIASSVVSFYLPLVVMVFVYSKVFQVAKRQLQKIDRSEGRFHAQNLSQVEQDRQGRHGQRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRDNLISKDVYILLNWLGYVNSGFNPLIY |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Keywords
- Domain
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusFragment
- Length275
- Mass (Da)31,521
- Last updated2002-10-01 v1
- ChecksumD2098BCDE98BCCC4
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V | ||||||
Non-terminal residue | 275 | |||||
Sequence: Y |