Q8IDN0 · PFS47_PLAF7

Function

function

Mediates evasion of the mosquito innate immune response by suppressing midgut nitration responses that are critical to activate the mosquito complement system. It is unclear whether the protein has a role in passive evasion by making the parasite invisible to the mosquito immune system, acts as a decoy to prevent recognition of another surface protein or anchors the decoy protein. Not required for female fertility.

Miscellaneous

Exhibits a high rate of non-synonymous polymorphism is different strains, suggesting that it adapts to different Anopheles vector species.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentplasma membrane
Cellular Componentside of membrane
Biological Processevasion of host immune response
Biological Processsymbiont-mediated perturbation of host cellular process
Biological Processsymbiont-mediated suppression of host innate immune response

Names & Taxonomy

Protein names

  • Recommended name
    Female gametocyte surface protein P47

Gene names

    • Name
      PFS47
    • Synonyms
      PF47
    • ORF names
      PF13_0248

Organism names

Accessions

  • Primary accession
    Q8IDN0

Proteomes

Organism-specific databases

Subcellular Location

Cell surface
Cell membrane
; Lipid-anchor, GPI-anchor
Note: Specifically present on the surface of female gametocytes.

Keywords

Phenotypes & Variants

Disruption phenotype

Reduced parasite survival in the mosquito. Parasites produce normal numbers of oocysts when included in the blood meal of the mosquito vector.

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000042357927-415Female gametocyte surface protein P47
Disulfide bond36↔62
Disulfide bond77↔152
Disulfide bond95↔150
Glycosylation106N-linked (GlcNAc...) asparagine
Glycosylation125N-linked (GlcNAc...) asparagine
Disulfide bond287↔315
Glycosylation324N-linked (GlcNAc...) asparagine
Disulfide bond332↔400
Disulfide bond341↔398
Lipidation415GPI-anchor amidated serine
PropeptidePRO_0000423580416-439Removed in mature form

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed only in female gametocytes following emergence from red blood cells.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-1826-Cys 1
Domain283-4156-Cys 2

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    439
  • Mass (Da)
    50,824
  • Last updated
    2003-03-01 v1
  • Checksum
    F9F0DA79A9806012
MCMGRMISIINIILFYFFLWVKKSISELLSSTQYVCDFYFNPLTNVKPTVVGSSEIYEEVGCTINNPTLGDHIVLICPKKNNGDFSNIEIVPTNCFESHLYSAYKNDSSAYHLEKLDIDKKYAINSSFSDFYLKILVIPNEYKSHKTIYCRCDNSKTEKNIPGQDKILKGKLGLVKIILRNQYNNIIELEKTKPIIHNKKDTYKYDIKLKESDILMFYMKEETIVESGNCEEILNTKINLLSNNNVVIKMPSIFINNINCMLSSQDQNNEKNYINLKADKTKHIDGCDFTKPKGKGIYKNGFIINDIPNEEERICTVHLWNKKNQTIAGIKCPYKLIPPYCFKHVLYEKEIDSQKTYKTFLLSDVLDTPNIEYYGNNKEGMYMLALPTKPEKTNKIRCICEQGGKKAVMELHIASTSTKYISMFLIFFLIVIFYMYVSI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL844509
EMBL· GenBank· DDBJ
CAD52591.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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