Q8AV97 · SLAA_PROFL

Function

function

Strong platelet aggregation inhibitor. Binds specifically to platelet glycoprotein Ibalpha (GP1BA) with high affinity and inhibits vWF-dependent platelet aggregation (PubMed:7599152).
Has also been observed to induce small agglutinates in washed platelets by binding to GPIb (PubMed:10688335).

Miscellaneous

Negative results: has no effect on ADP- and collagen-induced platelet aggregation in platelet rich plasma.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Snaclec flavocetin-A subunit alpha
  • Short names
    FL-A subunit alpha

Organism names

Accessions

  • Primary accession
    Q8AV97
  • Secondary accessions
    • Q9PRT2

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_000035529324-158Snaclec flavocetin-A subunit alpha
Disulfide bond27↔38
Disulfide bond55↔152
Disulfide bond104Interchain (with C-100 in subunit beta of heterodimeric partner)
Disulfide bond127↔144
Disulfide bond158Interchain (with C-26 in subunit beta of tetrameric partner)

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Interaction

Subunit

Tetramer of heterodimers of alpha and beta subunits (alphabeta)4; disulfide-linked.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-153C-type lectin

Sequence similarities

Belongs to the snaclec family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    158
  • Mass (Da)
    18,073
  • Last updated
    2003-03-01 v1
  • Checksum
    8C138650665CA454
MERLIFVSFGLLVVILSLSGTGADFDCIPGWSAYDRYCYQAFSKPKNWEDAESFCEEGVKTSHLVSIESSGEGDFVAQLVAEKIKTSFQYVWIGLRIQNKEQQCRSEWSDASSVNYENLVKQFSKKCYALKKGTELRTWFNVYCGTENPFVCKYTPEC

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict53in Ref. 2; AA sequence
Sequence conflict56in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY149341
EMBL· GenBank· DDBJ
AAN72438.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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