Q88RA3 · TAUD_PSEPK
- ProteinAlpha-ketoglutarate-dependent taurine dioxygenase
- GenetauD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids277 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the alpha-ketoglutarate-dependent hydroxylation of taurine yielding sulfite and aminoacetaldehyde after decomposition of an unstable intermediate.
Catalytic activity
- 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + H+ + succinate + sulfite
Cofactor
Note: Binds 1 Fe2+ ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 68 | taurine (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 71 | taurine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 93 | taurine (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 97 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 99 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 100 | taurine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 124 | 2-oxoglutarate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 253 | 2-oxoglutarate (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 253 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 264 | 2-oxoglutarate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 268 | 2-oxoglutarate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 268 | taurine (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | identical protein binding | |
Molecular Function | iron ion binding | |
Molecular Function | sulfonate dioxygenase activity | |
Molecular Function | taurine dioxygenase activity | |
Biological Process | sulfur compound catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-ketoglutarate-dependent taurine dioxygenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionQ88RA3
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000448494 | 1-277 | Alpha-ketoglutarate-dependent taurine dioxygenase | |||
Sequence: MSLTITPLSPALGAQISGVDISRDISAEERDAIEQALLQHQVLFLRDQPINPEQQARFAARFGDLHIHPIYPNVPDTPQVLVLDTAVTDVRDNAVWHTDVTFLPTPALGAVLSAKQLPAYGGDTLWASGIAAFEALSAPLREMLDGLTATHDFTKSFPLERFGTTPQDLARWEATRRNNPPLSHPVVRTHPVSGRKALFVNEGFTTRINELSELESDALLRLLFAHATRPEFSIRWRWQENDVAFWDNRVTQHFAVDDYRPNRRVMHRATILGDAPF |
Proteomic databases
Interaction
Subunit
Homotetramer; dimer of dimers.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q88RA3 | tauD Q88RA3 | 2 | EBI-7634056, EBI-7634056 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)31,098
- Last updated2003-06-01 v1
- ChecksumCFA7BB8DDA2DC601
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE015451 EMBL· GenBank· DDBJ | AAN65862.1 EMBL· GenBank· DDBJ | Genomic DNA |