Q864Q0 · SRY_TURTR
- ProteinSex-determining region Y protein
- GeneSRY
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids201 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity).
In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 54-122 | HMG box | ||||
Sequence: VKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYK |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Cellular Component | nucleus | |
Molecular Function | calmodulin binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | anatomical structure morphogenesis | |
Biological Process | cell differentiation | |
Biological Process | male sex determination | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | sex differentiation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSex-determining region Y protein
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Delphinidae > Tursiops
Accessions
- Primary accessionQ864Q0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000048709 | 1-201 | Sex-determining region Y protein | |||
Sequence: MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ |
Interaction
Subunit
Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form. Interaction with PARP1 impaired its DNA-binding activity.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 162-201 | Disordered | ||||
Sequence: LRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ | ||||||
Compositional bias | 185-201 | Polar residues | ||||
Sequence: LTPATGASQQLDKPAPQ |
Sequence similarities
Belongs to the SRY family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length201
- Mass (Da)23,096
- Last updated2003-06-01 v1
- Checksum7D1550E1F484AC37
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 185-201 | Polar residues | ||||
Sequence: LTPATGASQQLDKPAPQ |
Keywords
- Technical term