Q864Q0 · SRY_TURTR

Function

function

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity).
In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).

Features

Showing features for dna binding.

120120406080100120140160180200
TypeIDPosition(s)Description
DNA binding54-122HMG box

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear speck
Cellular Componentnucleus
Molecular Functioncalmodulin binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processanatomical structure morphogenesis
Biological Processcell differentiation
Biological Processmale sex determination
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processsex differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sex-determining region Y protein
  • Alternative names
    • Testis-determining factor

Gene names

    • Name
      SRY
    • Synonyms
      TDF

Organism names

Accessions

  • Primary accession
    Q864Q0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000487091-201Sex-determining region Y protein

Interaction

Subunit

Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form. Interaction with PARP1 impaired its DNA-binding activity.

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region162-201Disordered
Compositional bias185-201Polar residues

Sequence similarities

Belongs to the SRY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    201
  • Mass (Da)
    23,096
  • Last updated
    2003-06-01 v1
  • Checksum
    7D1550E1F484AC37
MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias185-201Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB108521
EMBL· GenBank· DDBJ
BAC75653.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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