Q79VE0 · ECTP_CORGL
- ProteinEctoine/glycine betaine/proline transporter EctP
- GeneectP
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids615 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Involved in the uptake of osmoprotectants. Can transport ectoine, proline and glycine betaine. Na+ is probably the coupling ion.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
63 μM | ectoine | |||||
333 μM | glycine betaine | |||||
1200 μM | proline | |||||
9100 μM | Na+ |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
27 nmol/min/mg | with ectoine as substrate | ||||
34 nmol/min/mg | with glycine betaine as substrate | ||||
34 nmol/min/mg | with proline as substrate |
Temperature Dependence
Optimum temperature is 25 degrees Celsius (irrespective of the state of osmotic stimulation).
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | symporter activity | |
Biological Process | amino acid transport | |
Biological Process | sodium ion transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameEctoine/glycine betaine/proline transporter EctP
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium
Accessions
- Primary accessionQ79VE0
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 24-44 | Helical | ||||
Sequence: FIFSISVGFIVVFVIATIALG | ||||||
Transmembrane | 62-82 | Helical | ||||
Sequence: LGWMYIGGVSLVFIFLMGIFA | ||||||
Transmembrane | 102-122 | Helical | ||||
Sequence: IVWFCMLFAGGVGAVLMFWGV | ||||||
Transmembrane | 156-176 | Helical | ||||
Sequence: FGIHMWVIMALPGLSLGYFIY | ||||||
Transmembrane | 207-227 | Helical | ||||
Sequence: LAIVGTTFGIAVSVGLGVLQI | ||||||
Transmembrane | 240-260 | Helical | ||||
Sequence: VSWVQLLIILIITAVACISVA | ||||||
Transmembrane | 275-295 | Helical | ||||
Sequence: IAMAVALMFFILFTGPTLTLL | ||||||
Transmembrane | 329-349 | Helical | ||||
Sequence: WTVFYWAWTICWSPYVGMFVA | ||||||
Transmembrane | 360-380 | Helical | ||||
Sequence: FIGGVLALPAIFGVVWFSIFG | ||||||
Transmembrane | 417-437 | Helical | ||||
Sequence: LTGIVSAFALVIIVIFFITSI | ||||||
Transmembrane | 463-483 | Helical | ||||
Sequence: WACTIGAVAGSLLIISPSSGI | ||||||
Transmembrane | 489-509 | Helical | ||||
Sequence: VVIIVAFPFFLVQFVMMFSLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000441731 | 1-615 | Ectoine/glycine betaine/proline transporter EctP | |||
Sequence: MSSNIAITTEPEGKNKKGLKSDPFIFSISVGFIVVFVIATIALGEKARTTFSAIAGWLLENLGWMYIGGVSLVFIFLMGIFASRYGRVKLGDDDDDPEHTLIVWFCMLFAGGVGAVLMFWGVAEPINHAFNVPMANEESMSEAAIVQAFAYTFYHFGIHMWVIMALPGLSLGYFIYKRKLPPRLSSVFSPILGKHIYSTPGKLIDVLAIVGTTFGIAVSVGLGVLQINAGMNKLWSTPQVSWVQLLIILIITAVACISVASGLDKGIKLLSNINIAMAVALMFFILFTGPTLTLLRFLVESFGIYASWMPNLMFWTDSFQDNPGWQGKWTVFYWAWTICWSPYVGMFVARISRGRTVREFIGGVLALPAIFGVVWFSIFGRAGIEVELSNPGFLTQPTVVEGDVPAALFNVLQEYPLTGIVSAFALVIIVIFFITSIDSAALVNDMFATGAENQTPTSYRVMWACTIGAVAGSLLIISPSSGIATLQEVVIIVAFPFFLVQFVMMFSLLKGMSEDAAAVRRVQTRQWEKTDTPEKLEEHSSQPAPGYDDEGNPLPMPALEHDEDGNIVIPGNVVIEGDLGVVGDVVDDPEEAQEMGSRFKIVEQTRPQSRDEYDI |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 524-544 | Basic and acidic residues | ||||
Sequence: TRQWEKTDTPEKLEEHSSQPA | ||||||
Region | 524-562 | Disordered | ||||
Sequence: TRQWEKTDTPEKLEEHSSQPAPGYDDEGNPLPMPALEHD | ||||||
Region | 589-615 | Disordered | ||||
Sequence: PEEAQEMGSRFKIVEQTRPQSRDEYDI |
Sequence similarities
Belongs to the BCCT transporter (TC 2.A.15) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length615
- Mass (Da)67,403
- Last updated2004-07-05 v1
- Checksum832D85A58CA14FE7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 524-544 | Basic and acidic residues | ||||
Sequence: TRQWEKTDTPEKLEEHSSQPA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ001436 EMBL· GenBank· DDBJ | CAA04760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BA000036 EMBL· GenBank· DDBJ | BAB99705.1 EMBL· GenBank· DDBJ | Genomic DNA |