Q76BE3 · Q76BE3_AMICA
- ProteinTrifunctional purine biosynthetic protein adenosine-3
- GeneGARS-AIRS-GART
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1010 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- (6R)-10-formyltetrahydrofolate + N1-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H+ + N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoribosylamine-glycine ligase activity | |
Molecular Function | phosphoribosylformylglycinamidine cyclo-ligase activity | |
Molecular Function | phosphoribosylglycinamide formyltransferase activity | |
Biological Process | 'de novo' IMP biosynthetic process | |
Biological Process | purine nucleobase biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTrifunctional purine biosynthetic protein adenosine-3
Including 3 domains:
- Recommended namePhosphoribosylamine--glycine ligase
- EC number
- Alternative names
- Recommended namePhosphoribosylformylglycinamidine cyclo-ligase
- EC number
- Alternative names
- Recommended namePhosphoribosylglycinamide formyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Holostei > Amiiformes > Amiidae > Amia
Accessions
- Primary accessionQ76BE3
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 111-318 | ATP-grasp | ||||
Sequence: KSFMDRHGIPTARWCSFTDAQEACNYIQGADFPALVVKASGLAAGKGVIVAADREQACQAVRDILQDKAFGLAGETVVVEELLEGEEVSCLCFSDGSTVAPMPPAQDHKRLLDGDQGPNTGGMGAYCPTPQVSEELLLQVRETVLQKTVDGMRQEGAPYVGVLYAGLMLTKDGPKVLEFNCRFGDPECQVLLPLLKSDLYEVLQDTLQ |
Sequence similarities
In the C-terminal section; belongs to the GART family.
In the N-terminal section; belongs to the GARS family.
In the central section; belongs to the AIR synthase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,010
- Mass (Da)106,895
- Last updated2004-07-05 v1
- ChecksumD7437E9C1882A5CA