Q76BE3 · Q76BE3_AMICA

  • Protein
    Trifunctional purine biosynthetic protein adenosine-3
  • Gene
    GARS-AIRS-GART
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylamine-glycine ligase activity
Molecular Functionphosphoribosylformylglycinamidine cyclo-ligase activity
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Trifunctional purine biosynthetic protein adenosine-3

Including 3 domains:

  • Recommended name
    Phosphoribosylamine--glycine ligase
  • EC number
  • Alternative names
    • Glycinamide ribonucleotide synthetase
      (GARS
      )
    • Phosphoribosylglycinamide synthetase
  • Recommended name
    Phosphoribosylformylglycinamidine cyclo-ligase
  • EC number
  • Alternative names
    • AIR synthase
      (AIRS
      )
    • Phosphoribosyl-aminoimidazole synthetase
  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      GARS-AIRS-GART

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Holostei > Amiiformes > Amiidae > Amia

Accessions

  • Primary accession
    Q76BE3

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain111-318ATP-grasp

Sequence similarities

In the C-terminal section; belongs to the GART family.
In the N-terminal section; belongs to the GARS family.
In the central section; belongs to the AIR synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,010
  • Mass (Da)
    106,895
  • Last updated
    2004-07-05 v1
  • Checksum
    D7437E9C1882A5CA
MAERVLVIGSGGREHALAWKLAQSPLVQQVLVAPGNAGTSSCGKISNSEVSVSNHAILAQYCKDHNVGLVVVGPEVPLAAGMVDDLMAAGVRSFGPSAKAAQLEASKSFSKSFMDRHGIPTARWCSFTDAQEACNYIQGADFPALVVKASGLAAGKGVIVAADREQACQAVRDILQDKAFGLAGETVVVEELLEGEEVSCLCFSDGSTVAPMPPAQDHKRLLDGDQGPNTGGMGAYCPTPQVSEELLLQVRETVLQKTVDGMRQEGAPYVGVLYAGLMLTKDGPKVLEFNCRFGDPECQVLLPLLKSDLYEVLQDTLQGKLATNPPAWLDKSAAVTVVVASEGYPGEYKKGVEITGLAQAKELDLQVFHAGTALREGRVVTCGGRVLTVTAVRPDLESALQCVNRGLDAVSFPGAVYRRDIGHRAIAFLRQPRGLTYKDSGVDIAAGNVLVDLIKPLAKATARKGCNAELGGFAGLFDLKAAGFSDPILVSGTDGVGTKLKIAQACDRHSSLGQDLVAMCVNDVLAQGAEPLFFLDYFSCGKLDVGVASSVIGGIAEACRMAGCALLGGETAEMPGVYGPGEYDLAGFCVGAVERGQMLPRLQDIGEGDLLVGLASSGVHSNGFSLVRRVLDLCGLQYDSPAPFGSLGQTVGEVLLTPTKIYSQLLQPVLRGGAVKAYAHITGGGLLENIPRVLPKGLAVDLDALLWRIPAVFSWLQREGALSEEEMGRTFNCGLGAVLVVGRQEAERVLKEVQGQEEAWIVGSLTRRQPGVEQVVVRNLQRSLQTGLTTPPDSSLGQDSTPRRRTRVAVLISGTGTNLQALIEQAKSPSSAAEIVLVVSNRPGVLGLKRAALAGIQTRVVDHKLYGSRAEFDGTVDRVLEEFGVEVVCLAGFMRILSGALVRKWNGKMLNVHPSLLPSFKGVHAHRQALQAGVRITGCTVHFVAEEVDAGAIIMQEVVPVLESDTEESLSERVKEAEHRAFPAAMELVASGAVCLGDDNRIVWSHTQLH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB111399
EMBL· GenBank· DDBJ
BAD17913.1
EMBL· GenBank· DDBJ
mRNA

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