Q73G09 · PDXH_WOLPM
- ProteinPyridoxine/pyridoxamine 5'-phosphate oxidase
- GenepdxH
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids216 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Catalytic activity
- pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4+
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 64-69 | FMN (UniProtKB | ChEBI) | ||||
Sequence: RVVLLK | ||||||
Binding site | 69 | substrate | ||||
Sequence: K | ||||||
Binding site | 79-80 | FMN (UniProtKB | ChEBI) | ||||
Sequence: FT | ||||||
Binding site | 85 | FMN (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 86 | FMN (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 108 | FMN (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 126 | substrate | ||||
Sequence: Y | ||||||
Binding site | 130 | substrate | ||||
Sequence: R | ||||||
Binding site | 134 | substrate | ||||
Sequence: S | ||||||
Binding site | 143-144 | FMN (UniProtKB | ChEBI) | ||||
Sequence: QS | ||||||
Binding site | 188 | FMN (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 194-196 | substrate | ||||
Sequence: RKH | ||||||
Binding site | 198 | FMN (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | FMN binding | |
Molecular Function | pyridoxamine phosphate oxidase activity | |
Biological Process | pyridoxine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyridoxine/pyridoxamine 5'-phosphate oxidase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Anaplasmataceae > Wolbachieae > Wolbachia
Accessions
- Primary accessionQ73G09
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000167771 | 1-216 | Pyridoxine/pyridoxamine 5'-phosphate oxidase | |||
Sequence: MAVALIFATRARIKILFFDMIFSLEKDPFDLFSKWYKAVLNSPCEQPTAMTLATCSKDCIPSARVVLLKEYSKEGFVFFTNVNSKKGKELTENPKAALVFHWIEFARQVRIEGEVKLLNDERTDKYFSSRALGSQISAWCSKQSSILKDWQDFEQAIKLKEKEFHNTQVSRPDFWVGFCVIPKVIEFWQEGEYRKHIRFRYTLVEGSDWKVEQLYP |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length216
- Mass (Da)25,349
- Last updated2004-07-05 v1
- Checksum64F83515D339E8FC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE017196 EMBL· GenBank· DDBJ | AAS14809.1 EMBL· GenBank· DDBJ | Genomic DNA |