Q6PTS4 · Q6PTS4_ANTME

Function

function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.

Pathway

Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionmethionine adenosyltransferase activity
Biological Processone-carbon metabolic process
Biological ProcessS-adenosylmethionine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosylmethionine synthase
  • EC number

Organism names

Accessions

  • Primary accession
    Q6PTS4

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-82S-adenosylmethionine synthetase N-terminal
Domain98-220S-adenosylmethionine synthetase central
Domain222-320S-adenosylmethionine synthetase C-terminal

Sequence similarities

Belongs to the AdoMet synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    321
  • Mass (Da)
    34,766
  • Last updated
    2004-07-05 v1
  • Checksum
    831023A14DEF19CB
ICDQVSDAVLDAHLKQDPYAKVACESVSKTGMILVAGEITSNAHVDYQSVIRNTIKRIGYDDSSKGFDFETRNVLVALEEQATEIAAAVHIDKKEEDIGAGDQGLMFGYATNETEELMPLTVVLAHGLTKKLAEERRKKNGQMSYLRPDCKSQVTVQYRMDDGCCVPLRVHTVVISTQHSGDVTQKQLRKDLADIVIPAVIPAKYLDKDTVFHFNPSGSFLIGGPKGGAGLTGRKIIVDTYGGWGAHGGGAFSGKDMTKVDRSAAYAARWVAKSLVAANVCKRALVQVAYAIGIAEPLSVTVWDYGTSDKSQDELLKLVND

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue321

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY580171
EMBL· GenBank· DDBJ
AAT06194.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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