Q6MVL2 · DUT_NEUCR

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site77-79substrate
Binding site91-94substrate
Binding site102substrate
Binding site145substrate
Binding site150-151substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut-1
    • ORF names
      B8J22.110, NCU10893

Organism names

Accessions

  • Primary accession
    Q6MVL2
  • Secondary accessions
    • A7UXB3

Proteomes

    • Identifier
    • Component
      Chromosome 1, Linkage Group I

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001829341-165Deoxyuridine 5'-triphosphate nucleotidohydrolase

Proteomic databases

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    165
  • Mass (Da)
    17,441
  • Last updated
    2004-07-05 v1
  • Checksum
    2A575A279571A25A
MTADTQTPVTKVDQAPPLLIKKLSDKARLPTRGSAFAAGYDIYASKETTIPARGKGLVETDISMAVPAGTYGRIAPRSGLAAKNFIDVGAGVIDADYRGQVKVLLFNHSDVDFVVNEGDRVAQLVLERIYTPEVVEVEQLEESVRGAGGFGSTGVGSGVGEQMKN

Sequence caution

The sequence EDO64923.1 differs from that shown. Reason: Erroneous initiation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX842627
EMBL· GenBank· DDBJ
CAE76286.1
EMBL· GenBank· DDBJ
Genomic DNA
CM002236
EMBL· GenBank· DDBJ
EDO64923.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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