Q6MVL2 · DUT_NEUCR
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- Genedut-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids165 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = diphosphate + dUMP + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 77-79 | substrate | ||||
Sequence: RSG | ||||||
Binding site | 91-94 | substrate | ||||
Sequence: GVID | ||||||
Binding site | 102 | substrate | ||||
Sequence: K | ||||||
Binding site | 145 | substrate | ||||
Sequence: R | ||||||
Binding site | 150-151 | substrate | ||||
Sequence: FG |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora
Accessions
- Primary accessionQ6MVL2
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000182934 | 1-165 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | |||
Sequence: MTADTQTPVTKVDQAPPLLIKKLSDKARLPTRGSAFAAGYDIYASKETTIPARGKGLVETDISMAVPAGTYGRIAPRSGLAAKNFIDVGAGVIDADYRGQVKVLLFNHSDVDFVVNEGDRVAQLVLERIYTPEVVEVEQLEESVRGAGGFGSTGVGSGVGEQMKN |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length165
- Mass (Da)17,441
- Last updated2004-07-05 v1
- Checksum2A575A279571A25A
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX842627 EMBL· GenBank· DDBJ | CAE76286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM002236 EMBL· GenBank· DDBJ | EDO64923.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |