Q6MSL3 · FOLD_MYCMS

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site164-166NADP+ (UniProtKB | ChEBI)
Binding site230NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • Ordered locus names
      MSC_0758

Organism names

Accessions

  • Primary accession
    Q6MSL3

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002684081-288Bifunctional protein FolD

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    288
  • Mass (Da)
    32,102
  • Last updated
    2006-12-12 v2
  • Checksum
    847A202BFDCC77FE
MVILDGKLVSKQIKQTLKKQIDTYLNKNYKKPKLAVILIGNDPASELYVSNKIKACNLVGIESVLLRFGQNITSEMLSDQINQLNNDNSVDAILLQLPLPKHLDEQEFLQAIDPLKDVDGFHYINQGKMLEGYDTIYPCTPIGIINLLKAYNIDVRSKDITIIGTSNIVGKPLAIMLSNMGATISMCNKNTKSLKKYTKRSDIVISTTGKQALIKKDMIKKNAIVIDVGIIKDPITNKIVGDVDFENVKELCSYITPVPGGVGPMTVSMLLENTFKLYKLHIKENYEN

Sequence caution

The sequence CAE77376.1 differs from that shown. Reason: Erroneous termination Truncated C-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX293980
EMBL· GenBank· DDBJ
CAE77376.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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