Q6MSL3 · FOLD_MYCMS
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids288 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methenyltetrahydrofolate + NADPH
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Mycoplasmatota > Mollicutes > Mycoplasmataceae > Mycoplasma
Accessions
- Primary accessionQ6MSL3
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000268408 | 1-288 | Bifunctional protein FolD | |||
Sequence: MVILDGKLVSKQIKQTLKKQIDTYLNKNYKKPKLAVILIGNDPASELYVSNKIKACNLVGIESVLLRFGQNITSEMLSDQINQLNNDNSVDAILLQLPLPKHLDEQEFLQAIDPLKDVDGFHYINQGKMLEGYDTIYPCTPIGIINLLKAYNIDVRSKDITIIGTSNIVGKPLAIMLSNMGATISMCNKNTKSLKKYTKRSDIVISTTGKQALIKKDMIKKNAIVIDVGIIKDPITNKIVGDVDFENVKELCSYITPVPGGVGPMTVSMLLENTFKLYKLHIKENYEN |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length288
- Mass (Da)32,102
- Last updated2006-12-12 v2
- Checksum847A202BFDCC77FE
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX293980 EMBL· GenBank· DDBJ | CAE77376.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |