Q6C141 · DUT_YARLI

Function

function

Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site63dUMP (UniProtKB | ChEBI)
Binding site76dUMP (UniProtKB | ChEBI)
Binding site79dUMP (UniProtKB | ChEBI)
Binding site82dUMP (UniProtKB | ChEBI)
Binding site87dUMP (UniProtKB | ChEBI)
Binding site132dUMP (UniProtKB | ChEBI)
Binding site137dUMP (UniProtKB | ChEBI)
Binding site138dUMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      DUT1
    • Ordered locus names
      YALI0F19448g

Organism names

Accessions

  • Primary accession
    Q6C141

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001829361-157Deoxyuridine 5'-triphosphate nucleotidohydrolase

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region125-157Disordered
Compositional bias142-157Basic and acidic residues

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    157
  • Mass (Da)
    16,857
  • Last updated
    2004-08-16 v1
  • Checksum
    1BB1C6A534555AEF
MSLKVAFLNENARAPTRGSVHAAGYDLYAAEEKTIPANGRGLVDLGLSMSIPEGTYARIAPRSGLAVKNGLSTGAGVIDYDYRGPVKVMLFNHSTEDFNVTIGDRVAQMILERIVTPEVQVVQTNDLESTERGAGGFGSTGINDEKKRKLDEAEAKE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias142-157Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR382132
EMBL· GenBank· DDBJ
CAG78430.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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