Q6C141 · DUT_YARLI
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- GeneDUT1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids157 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = diphosphate + dUMP + H+This reaction proceeds in the forward direction.
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 63 | dUMP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 76 | dUMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 79 | dUMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 82 | dUMP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 87 | dUMP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 132 | dUMP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 137 | dUMP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 138 | dUMP (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Dipodascaceae > Yarrowia
Accessions
- Primary accessionQ6C141
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000182936 | 1-157 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | |||
Sequence: MSLKVAFLNENARAPTRGSVHAAGYDLYAAEEKTIPANGRGLVDLGLSMSIPEGTYARIAPRSGLAVKNGLSTGAGVIDYDYRGPVKVMLFNHSTEDFNVTIGDRVAQMILERIVTPEVQVVQTNDLESTERGAGGFGSTGINDEKKRKLDEAEAKE |
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 125-157 | Disordered | ||||
Sequence: NDLESTERGAGGFGSTGINDEKKRKLDEAEAKE | ||||||
Compositional bias | 142-157 | Basic and acidic residues | ||||
Sequence: INDEKKRKLDEAEAKE |
Sequence similarities
Belongs to the dUTPase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length157
- Mass (Da)16,857
- Last updated2004-08-16 v1
- Checksum1BB1C6A534555AEF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 142-157 | Basic and acidic residues | ||||
Sequence: INDEKKRKLDEAEAKE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR382132 EMBL· GenBank· DDBJ | CAG78430.1 EMBL· GenBank· DDBJ | Genomic DNA |