Q645U5 · T2R40_PONPY

Function

function

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionbitter taste receptor activity
Molecular FunctionG protein-coupled receptor activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Taste receptor type 2 member 40
  • Short names
    T2R40

Gene names

    • Name
      TAS2R40

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo

Accessions

  • Primary accession
    Q645U5

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-14Extracellular
Transmembrane15-35Helical; Name=1
Topological domain36-58Cytoplasmic
Transmembrane59-79Helical; Name=2
Topological domain80-100Extracellular
Transmembrane101-121Helical; Name=3
Topological domain122-140Cytoplasmic
Transmembrane141-162Helical; Name=4
Topological domain163-190Extracellular
Transmembrane191-211Helical; Name=5
Topological domain212-247Cytoplasmic
Transmembrane248-268Helical; Name=6
Topological domain269-276Extracellular
Transmembrane277-297Helical; Name=7
Topological domain298-323Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000822921-323Taste receptor type 2 member 40
Glycosylation170N-linked (GlcNAc...) asparagine
Glycosylation179N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    323
  • Mass (Da)
    36,822
  • Last updated
    2004-10-25 v1
  • Checksum
    D8D11B5E932C1E4F
MATVNTDATDKDISTFKVTFTLVVSGIECITGILGSGFITAIYGAEWARGKTLPTGDHIMLMLSFSRLLLQIWMMLENIFSLLFRIVYNQNTVYILFKVITVFLNHSNLWFAAWLKVFYCLRIANFNHPLFFLMKRKIIVLMPWLLRLSVLVSLSFSFPLSRHVFNVYVNSSIPISSSNSTEKKYFSETNMVNLVFFYNMGIFVPLIMFILAATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIKATSYFLILYIFNAIALFLSMSNIFDTYSSWNILCKIIMAAYPAGHSVQLILGNPGLRRAWKRFQHQVPLYLKGQTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY724988
EMBL· GenBank· DDBJ
AAU21174.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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