Q645U5 · T2R40_PONPY
- ProteinTaste receptor type 2 member 40
- GeneTAS2R40
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids323 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
Miscellaneous
Several bitter taste receptors are expressed in a single taste receptor cell.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | bitter taste receptor activity | |
Molecular Function | G protein-coupled receptor activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTaste receptor type 2 member 40
- Short namesT2R40
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionQ645U5
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-14 | Extracellular | ||||
Sequence: MATVNTDATDKDIS | ||||||
Transmembrane | 15-35 | Helical; Name=1 | ||||
Sequence: TFKVTFTLVVSGIECITGILG | ||||||
Topological domain | 36-58 | Cytoplasmic | ||||
Sequence: SGFITAIYGAEWARGKTLPTGDH | ||||||
Transmembrane | 59-79 | Helical; Name=2 | ||||
Sequence: IMLMLSFSRLLLQIWMMLENI | ||||||
Topological domain | 80-100 | Extracellular | ||||
Sequence: FSLLFRIVYNQNTVYILFKVI | ||||||
Transmembrane | 101-121 | Helical; Name=3 | ||||
Sequence: TVFLNHSNLWFAAWLKVFYCL | ||||||
Topological domain | 122-140 | Cytoplasmic | ||||
Sequence: RIANFNHPLFFLMKRKIIV | ||||||
Transmembrane | 141-162 | Helical; Name=4 | ||||
Sequence: LMPWLLRLSVLVSLSFSFPLSR | ||||||
Topological domain | 163-190 | Extracellular | ||||
Sequence: HVFNVYVNSSIPISSSNSTEKKYFSETN | ||||||
Transmembrane | 191-211 | Helical; Name=5 | ||||
Sequence: MVNLVFFYNMGIFVPLIMFIL | ||||||
Topological domain | 212-247 | Cytoplasmic | ||||
Sequence: AATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIK | ||||||
Transmembrane | 248-268 | Helical; Name=6 | ||||
Sequence: ATSYFLILYIFNAIALFLSMS | ||||||
Topological domain | 269-276 | Extracellular | ||||
Sequence: NIFDTYSS | ||||||
Transmembrane | 277-297 | Helical; Name=7 | ||||
Sequence: WNILCKIIMAAYPAGHSVQLI | ||||||
Topological domain | 298-323 | Cytoplasmic | ||||
Sequence: LGNPGLRRAWKRFQHQVPLYLKGQTL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082292 | 1-323 | Taste receptor type 2 member 40 | |||
Sequence: MATVNTDATDKDISTFKVTFTLVVSGIECITGILGSGFITAIYGAEWARGKTLPTGDHIMLMLSFSRLLLQIWMMLENIFSLLFRIVYNQNTVYILFKVITVFLNHSNLWFAAWLKVFYCLRIANFNHPLFFLMKRKIIVLMPWLLRLSVLVSLSFSFPLSRHVFNVYVNSSIPISSSNSTEKKYFSETNMVNLVFFYNMGIFVPLIMFILAATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIKATSYFLILYIFNAIALFLSMSNIFDTYSSWNILCKIIMAAYPAGHSVQLILGNPGLRRAWKRFQHQVPLYLKGQTL | ||||||
Glycosylation | 170 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 179 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Structure
Sequence
- Sequence statusComplete
- Length323
- Mass (Da)36,822
- Last updated2004-10-25 v1
- ChecksumD8D11B5E932C1E4F