Q5ZYK6 · DAPF_LEGPH

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site, site.

127720406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site13substrate
Binding site46substrate
Binding site66substrate
Active site75Proton donor
Binding site76-77substrate
Binding site160substrate
Site162Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site193substrate
Site211Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site211-212substrate
Active site220Proton acceptor
Binding site221-222substrate
Site271Important for dimerization

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondiaminopimelate epimerase activity
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      dapF
    • Ordered locus names
      lpg0366

Organism names

Accessions

  • Primary accession
    Q5ZYK6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000118951-277Diaminopimelate epimerase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    29,953
  • Last updated
    2004-11-23 v1
  • Checksum
    DE73BE862397C9A7
MGIKFTKMHGLGNDFIVLDGVNQSIQLTVEQIQKLANRHTGIGFDQCLLIESSQTEGIDFNYRIFNADGQEVGQCGNGARCIALFARYYGLTAKNKLTVATKTTLMDLIINEDNSVSVNMGVPRLAPGEIPLLADRQSPEYSLELNNGNTVNLHAISVGNPHAVLLVENIDTAPVNSLGQQISFHPQFPEQVNVGFMQIINHEKINLRVYERGCGETIACGSGAVAAAAIARLFYNLSDKITVHLPGGDLCIQWPCPTAPIILTGPAAFVYEGTLLS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017354
EMBL· GenBank· DDBJ
AAU26463.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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