Q5WNX1 · BCRB_ENTFL
- ProteinBacitracin transport permease protein BcrB
- GenebcrB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids249 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Essential for high-level bacitracin resistance (PubMed:15388429).
Part of the ABC transporter complex BcrAB. Probably responsible for the translocation of the substrate across the membrane (Probable)
Part of the ABC transporter complex BcrAB. Probably responsible for the translocation of the substrate across the membrane (Probable)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Biological Process | response to antibiotic |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameBacitracin transport permease protein BcrB
Gene names
Encoded on
- Plasmid pJM01
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Enterococcus
Accessions
- Primary accessionQ5WNX1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 17-37 | Helical | ||||
Sequence: MVLISVAGVLSTPLLMLIEAL | ||||||
Transmembrane | 58-78 | Helical | ||||
Sequence: VLYIMLLVNMMIYVAIAAYLY | ||||||
Transmembrane | 108-128 | Helical | ||||
Sequence: LLLWIVMLTLVTWAGIFIVCG | ||||||
Transmembrane | 141-161 | Helical | ||||
Sequence: LLVAISWLPKFLFGGILMFLT | ||||||
Transmembrane | 174-194 | Helical | ||||
Sequence: GFVAPVIASAVIVMGSVALSN | ||||||
Transmembrane | 220-240 | Helical | ||||
Sequence: PLALAIGIIILVSAVGFFMTF |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Disruption mutant is sensitive to bacitracin.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000447367 | 1-249 | Bacitracin transport permease protein BcrB | |||
Sequence: MLNLISCELSKLKRSKMVLISVAGVLSTPLLMLIEALQTHFDKPEIIFTLSDIYSDSVLYIMLLVNMMIYVAIAAYLYSREYTENTLKTILPIPISRTKLLIGKFCTLLLWIVMLTLVTWAGIFIVCGLYHVVFTLEGYSLLVAISWLPKFLFGGILMFLTTSPFVFIAFKTKGFVAPVIASAVIVMGSVALSNQELGALYPWTATFFLIDGRIESTGYPLALAIGIIILVSAVGFFMTFHHFKKEDLK |
Expression
Induction
Transcription is activated by the regulatory protein BcrR in the presence of bacitracin.
Interaction
Subunit
The complex is probably composed of two ATP-binding proteins (BcrA) and two transmembrane proteins (BcrB).
Structure
Sequence
- Sequence statusComplete
- Length249
- Mass (Da)27,788
- Last updated2004-11-23 v1
- Checksum1A36D0AF3717CF49
Keywords
- Technical term