Q5RBN0 · MID51_PONAB

Function

function

Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.

Features

Showing features for binding site.

146350100150200250300350400450
TypeIDPosition(s)Description
Binding site187ADP (UniProtKB | ChEBI)
Binding site189ADP (UniProtKB | ChEBI)
Binding site201ADP (UniProtKB | ChEBI)
Binding site340ADP (UniProtKB | ChEBI)
Binding site342ADP (UniProtKB | ChEBI)
Binding site368ADP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Molecular Functionnucleotide binding
Biological Processmitochondrial fission
Biological Processpositive regulation of mitochondrial fission
Biological Processpositive regulation of mitochondrial fusion
Biological Processpositive regulation of protein targeting to membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial dynamics protein MID51
  • Alternative names
    • Mitochondrial dynamics protein of 51 kDa homolog
    • Mitochondrial elongation factor 1
    • Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like

Gene names

    • Name
      MIEF1
    • Synonyms
      MID51, SMCR7L

Organism names

Accessions

  • Primary accession
    Q5RBN0

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-23Mitochondrial intermembrane
Transmembrane24-46Helical
Topological domain47-463Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003104501-463Mitochondrial dynamics protein MID51
Modified residue55Phosphoserine
Modified residue59Phosphoserine
Modified residue79Phosphoserine
Modified residue94Phosphoserine

Keywords

Interaction

Subunit

Homodimer. Interacts with DNM1L.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region49-195Dimerization
Region57-79Disordered
Region104-123Disordered
Region160-169Important for interaction with DNM1L
Region234-243Important for interaction with DNM1L

Sequence similarities

Belongs to the MID49/MID51 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    463
  • Mass (Da)
    51,199
  • Last updated
    2004-12-21 v1
  • Checksum
    CAFEBA4D12715D93
MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSPTRLSHSGKRSWEEPNWMGSPQLLNRDMKTGLSRSLQTLPTDSSAFDTDTFCPPRPKPVARKGQVDLKKSRLRMSLQEKLLPYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMPLRDVYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEYFPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEVQYERDKHLFIDFLPSVTLGDTVLVAKPHRLAQYDNLWRLSLRPAETARLRALDQADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLEAGVLPSALNPKVNLFAELTPEEIDELGYTLYCSLSEPEVLLQT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR858608
EMBL· GenBank· DDBJ
CAH90830.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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