Q5LX16 · PK21A_RUEPO
- ProteinNDP-polyphosphate phosphotransferase 1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids305 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Uses inorganic polyphosphate (polyP) as a donor to convert NDP to NTP. PolyP hydrolysis is slightly faster with GDP, but it can also use ADP, CDP and UDP.
Catalytic activity
- [phosphate](n) + ATP = [phosphate](n+1) + ADP
- [phosphate](n) + CTP = [phosphate](n+1) + CDP
- [phosphate](n) + GTP = [phosphate](n+1) + GDP
- [phosphate](n) + UTP = [phosphate](n+1) + UDP
Activity regulation
Shows little dependence on metals.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
1.2 mM | GDP |
kcat is 251 min-1 with GDP as substrate.
pH Dependence
Has two pH optima at 8 and 10.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | polyphosphate kinase activity | |
Biological Process | phosphorus metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNDP-polyphosphate phosphotransferase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Roseobacteraceae > Ruegeria
Accessions
- Primary accessionQ5LX16
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000442593 | 1-305 | NDP-polyphosphate phosphotransferase 1 | |||
Sequence: MTHESDDPSLDWLEAELEDSLDEDFEIEFSEPMLSMEIRRIYKDQRPDLLDRQVYFRNLLRLQAELIKLQDWVQHTNSKVLIIMEGRDAAGKGGVIKRITQRLNPRIARVVALPAPSRREQSQWYFQRYVPYLPSGGEMVLFDRSWYNRAGVERVMGFATEDQVEQFFQDVPEFERMLVRSGIILLKYWFSITDEEQQLRFLMRVHDPMKQWKLSPMDLESRIRWEQYTKAKEQMFSRTNIPEAPWYIVEGNDKKRERLNCIEHLLSKIPYEDIPHEKVTLPDRRYNPDYERQVLPDELYVPKVY |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length305
- Mass (Da)36,711
- Last updated2005-02-01 v1
- Checksum46E32B3FA063BD4B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000031 EMBL· GenBank· DDBJ | AAV93549.1 EMBL· GenBank· DDBJ | Genomic DNA |