Q5AKZ2 · GUP1_CANAL

Function

function

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Acts only on GPI-anchored proteins, but not on free GPI lipids. Also involved in lipid metabolism, having profound effects on sphingolipid-sterol-ordered domains integrity and assembly. Involved in cell integrity and apoptosis (By similarity).
Plays a role in virulence and antifungal resistance (PubMed:20843317).

Features

Showing features for active site.

158450100150200250300350400450500550
TypeIDPosition(s)Description
Active site471

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Molecular FunctionO-acyltransferase activity
Biological Processcellular response to starvation
Biological Processfilamentous growth
Biological Processfilamentous growth of a population of unicellular organisms in response to biotic stimulus
Biological Processfilamentous growth of a population of unicellular organisms in response to starvation
Biological ProcessGPI anchor biosynthetic process
Biological Processsingle-species biofilm formation on inanimate substrate

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Membrane-bound O-acyltransferase GUP1
  • Alternative names
    • Glycerol uptake protein 1

Gene names

    • Name
      GUP1
    • ORF names
      orf19.4985
    • Ordered locus names
      CAALFM_C113540WA

Organism names

Accessions

  • Primary accession
    Q5AKZ2

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-41Extracellular
Transmembrane42-62Helical
Topological domain63-109Cytoplasmic
Transmembrane110-130Helical
Topological domain131-145Extracellular
Transmembrane146-166Helical
Topological domain167-182Cytoplasmic
Transmembrane183-203Helical
Topological domain204-295Extracellular
Transmembrane296-316Helical
Topological domain317-343Cytoplasmic
Transmembrane344-364Helical
Topological domain365-373Extracellular
Transmembrane374-394Helical
Topological domain395-456Cytoplasmic
Transmembrane457-477Helical
Transmembrane478-498Helical
Topological domain499-509Cytoplasmic
Transmembrane510-530Helical
Topological domain531-550Extracellular
Transmembrane551-571Helical
Topological domain572-584Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Changes ergosterol plasma membrane constitution and distribution and presents an increased resistance to azoles. Impairs the development of hyphae, adhesion, to invasion, and formation of biofilms, all of which are significant virulence factors.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004515851-584Membrane-bound O-acyltransferase GUP1

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    584
  • Mass (Da)
    68,733
  • Last updated
    2005-04-26 v1
  • Checksum
    D636040B1B4C245F
MNYLSQLGKLFSLETLDTRLNPTTNPIKRQSIIKKANPTSRWSTLEFKIYLTILIIVVPLMIKAAMESSNETNPNYPRFQHLLSDGWILGRKVDNSDQQYRFFRNNFPLLCGLIFIHVTLRKLINTFIIIPNGRYNNNFKRTYFDLIFGIIFLIGAHGINVFKISFHLFINYLIGKYIKNYKLAIWCTWIYGIFSLFFNEWFGDSSFGLSIFVNGSGYYTGIIPRWDVFYNFTLLRMLSFNLDYIERERKLGNNDGQLNLNKQENINGADNPPTLLNLDDRQRLSAPLPLDDYNVSNYIAYISYTPLFIAGPIITFNDYVYQSNYQQSSTTQNYQRIFMYAIRFLFCLLVMEFLLHFMYVVAVSKTKAWDGDTPFQISMLGMFNLNLIWLKLLIPWRLFRLWALLDGIDPPENMIRCMDNNFSALAFWRAWHRSYNRWVIRYIYIPMGGSGTGKYRIINSLLVFSFVAIWHDIELKLLMWGWLVVIFLIPEISATLIFSKYNKNWWYRYLCGIGAVINIWMMMIANLVGFCLGTDGMWKLLHDLFQTFEGGRFFIISSICLFVGAQIMFELRESELRRAIDVRC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017623
EMBL· GenBank· DDBJ
AOW26956.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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