Q5AKZ2 · GUP1_CANAL
- ProteinMembrane-bound O-acyltransferase GUP1
- GeneGUP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids584 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Acts only on GPI-anchored proteins, but not on free GPI lipids. Also involved in lipid metabolism, having profound effects on sphingolipid-sterol-ordered domains integrity and assembly. Involved in cell integrity and apoptosis (By similarity).
Plays a role in virulence and antifungal resistance (PubMed:20843317).
Plays a role in virulence and antifungal resistance (PubMed:20843317).
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 471 | |||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | mitochondrial membrane | |
Cellular Component | plasma membrane | |
Molecular Function | O-acyltransferase activity | |
Biological Process | cellular response to starvation | |
Biological Process | filamentous growth | |
Biological Process | filamentous growth of a population of unicellular organisms in response to biotic stimulus | |
Biological Process | filamentous growth of a population of unicellular organisms in response to starvation | |
Biological Process | GPI anchor biosynthetic process | |
Biological Process | single-species biofilm formation on inanimate substrate |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameMembrane-bound O-acyltransferase GUP1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5AKZ2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-41 | Extracellular | ||||
Sequence: MNYLSQLGKLFSLETLDTRLNPTTNPIKRQSIIKKANPTSR | ||||||
Transmembrane | 42-62 | Helical | ||||
Sequence: WSTLEFKIYLTILIIVVPLMI | ||||||
Topological domain | 63-109 | Cytoplasmic | ||||
Sequence: KAAMESSNETNPNYPRFQHLLSDGWILGRKVDNSDQQYRFFRNNFPL | ||||||
Transmembrane | 110-130 | Helical | ||||
Sequence: LCGLIFIHVTLRKLINTFIII | ||||||
Topological domain | 131-145 | Extracellular | ||||
Sequence: PNGRYNNNFKRTYFD | ||||||
Transmembrane | 146-166 | Helical | ||||
Sequence: LIFGIIFLIGAHGINVFKISF | ||||||
Topological domain | 167-182 | Cytoplasmic | ||||
Sequence: HLFINYLIGKYIKNYK | ||||||
Transmembrane | 183-203 | Helical | ||||
Sequence: LAIWCTWIYGIFSLFFNEWFG | ||||||
Topological domain | 204-295 | Extracellular | ||||
Sequence: DSSFGLSIFVNGSGYYTGIIPRWDVFYNFTLLRMLSFNLDYIERERKLGNNDGQLNLNKQENINGADNPPTLLNLDDRQRLSAPLPLDDYNV | ||||||
Transmembrane | 296-316 | Helical | ||||
Sequence: SNYIAYISYTPLFIAGPIITF | ||||||
Topological domain | 317-343 | Cytoplasmic | ||||
Sequence: NDYVYQSNYQQSSTTQNYQRIFMYAIR | ||||||
Transmembrane | 344-364 | Helical | ||||
Sequence: FLFCLLVMEFLLHFMYVVAVS | ||||||
Topological domain | 365-373 | Extracellular | ||||
Sequence: KTKAWDGDT | ||||||
Transmembrane | 374-394 | Helical | ||||
Sequence: PFQISMLGMFNLNLIWLKLLI | ||||||
Topological domain | 395-456 | Cytoplasmic | ||||
Sequence: PWRLFRLWALLDGIDPPENMIRCMDNNFSALAFWRAWHRSYNRWVIRYIYIPMGGSGTGKYR | ||||||
Transmembrane | 457-477 | Helical | ||||
Sequence: IINSLLVFSFVAIWHDIELKL | ||||||
Transmembrane | 478-498 | Helical | ||||
Sequence: LMWGWLVVIFLIPEISATLIF | ||||||
Topological domain | 499-509 | Cytoplasmic | ||||
Sequence: SKYNKNWWYRY | ||||||
Transmembrane | 510-530 | Helical | ||||
Sequence: LCGIGAVINIWMMMIANLVGF | ||||||
Topological domain | 531-550 | Extracellular | ||||
Sequence: CLGTDGMWKLLHDLFQTFEG | ||||||
Transmembrane | 551-571 | Helical | ||||
Sequence: GRFFIISSICLFVGAQIMFEL | ||||||
Topological domain | 572-584 | Cytoplasmic | ||||
Sequence: RESELRRAIDVRC |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Changes ergosterol plasma membrane constitution and distribution and presents an increased resistance to azoles. Impairs the development of hyphae, adhesion, to invasion, and formation of biofilms, all of which are significant virulence factors.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000451585 | 1-584 | Membrane-bound O-acyltransferase GUP1 | |||
Sequence: MNYLSQLGKLFSLETLDTRLNPTTNPIKRQSIIKKANPTSRWSTLEFKIYLTILIIVVPLMIKAAMESSNETNPNYPRFQHLLSDGWILGRKVDNSDQQYRFFRNNFPLLCGLIFIHVTLRKLINTFIIIPNGRYNNNFKRTYFDLIFGIIFLIGAHGINVFKISFHLFINYLIGKYIKNYKLAIWCTWIYGIFSLFFNEWFGDSSFGLSIFVNGSGYYTGIIPRWDVFYNFTLLRMLSFNLDYIERERKLGNNDGQLNLNKQENINGADNPPTLLNLDDRQRLSAPLPLDDYNVSNYIAYISYTPLFIAGPIITFNDYVYQSNYQQSSTTQNYQRIFMYAIRFLFCLLVMEFLLHFMYVVAVSKTKAWDGDTPFQISMLGMFNLNLIWLKLLIPWRLFRLWALLDGIDPPENMIRCMDNNFSALAFWRAWHRSYNRWVIRYIYIPMGGSGTGKYRIINSLLVFSFVAIWHDIELKLLMWGWLVVIFLIPEISATLIFSKYNKNWWYRYLCGIGAVINIWMMMIANLVGFCLGTDGMWKLLHDLFQTFEGGRFFIISSICLFVGAQIMFELRESELRRAIDVRC |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the membrane-bound acyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length584
- Mass (Da)68,733
- Last updated2005-04-26 v1
- ChecksumD636040B1B4C245F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017623 EMBL· GenBank· DDBJ | AOW26956.1 EMBL· GenBank· DDBJ | Genomic DNA |