Q56586 · NQRA_VIBAL

  • Protein
    Na(+)-translocating NADH-quinone reductase subunit A
  • Gene
    nqrA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

Catalytic activity

Activity regulation

This reaction is tightly coupled to the Na+ pumping activity and specifically requires Na+ for activity. Inhibited by korormicin and 2-N-heptyl-4-hydroxyquinoline N-oxide (HQNO).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Biological Processsodium ion transport

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 3.D.5.1.1the na+-translocating nadh:quinone dehydrogenase (na-ndh or nqr) family

Names & Taxonomy

Protein names

  • Recommended name
    Na(+)-translocating NADH-quinone reductase subunit A
  • EC number
  • Short names
    Na(+)-NQR subunit A
    ; Na(+)-translocating NQR subunit A
  • Alternative names
    • NQR complex subunit A
    • NQR-1 subunit A

Gene names

    • Name
      nqrA
    • Synonyms
      nqr1

Organism names

  • Taxonomic identifier
  • Strain
    • NCIMB 11038 / LMG 3418
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio

Accessions

  • Primary accession
    Q56586

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002142031-446Na+-translocating NADH-quinone reductase subunit A

Interaction

Subunit

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the NqrA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    446
  • Mass (Da)
    48,623
  • Last updated
    1996-11-01 v1
  • Checksum
    6D65ACAA53FE515C
MITIKKGLDLPIAGTPSQVINDGKTIKKVALLGEEYVGMRPTMHVRVGDEVKKAQVLFEDKKNPGVKFTAPAAGKVIEVNRGAKRVLQSVVIEVAGEEQVTFDKFEAAQLSGLDREVIKTQLVDSGLWTALRTRPFSKVPAIESSTKAIFVTAMDTNPLAAKPELIINEQQEAFIAGLDILSALTEGKVYVCKSGTSLPRSSQSNVEEHVFDGPHPAGLAGTHMHFLYPVNAENVAWSINYQDVIAFGKLFLTGELYTDRVVSLAGPVVNNPRLVRTVIGASLDDLTDNELMPGEVRVISGSVLTGTHATGPHAYLGRYHQQVSVLREGREKELFGWAMPGKNKFSVTRSFLGHVFKGQLFNMTTTTNGSDRSMVPIGNYERVMPLDMEPTLLLRDLCAGDTDSAQALGALELDEEDLALCTFVCPGKYEYGTLLRECLDTIEKEG

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict337in Ref. 4; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z37111
EMBL· GenBank· DDBJ
CAA85476.1
EMBL· GenBank· DDBJ
Genomic DNA
AB008030
EMBL· GenBank· DDBJ
BAA22910.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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