Q56582 · NQRC_VIBAL
- ProteinNa(+)-translocating NADH-quinone reductase subunit C
- GenenqrC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids256 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Catalytic activity
- a ubiquinone + H+ + n Na+(in) + NADH = a ubiquinol + n Na+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + CHEBI:15378 + n Na+ (in)CHEBI:29101+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + n Na+ (out)CHEBI:29101+ CHEBI:57540
Cofactor
Activity regulation
This reaction is tightly coupled to the Na+ pumping activity and specifically requires Na+ for activity. Inhibited by korormicin and 2-N-heptyl-4-hydroxyquinoline N-oxide (HQNO).
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | FMN binding | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
Biological Process | sodium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameNa(+)-translocating NADH-quinone reductase subunit C
- EC number
- Short namesNa(+)-NQR subunit C ; Na(+)-translocating NQR subunit C
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio
Accessions
- Primary accessionQ56582
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-32 | Helical | ||||
Sequence: LGVVIGLSLVCSIIVSTAAVG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000214221 | 2-256 | Na+-translocating NADH-quinone reductase subunit C | |||
Sequence: ASNNDSIKKTLGVVIGLSLVCSIIVSTAAVGLRDKQKANAVLDKQSKIVEVAGIDANGKKVPELFAEYIEPRLVDLETGNFTEGNASTYDQREASKDAERSIALTPEEDVADIRRRANTAVVYLVKDQDEVQKVILPMHGKGLWSMMYAFVAVETDGNTVSAITYYEQGETPGLGGEVENPSWRDQFIGKKLYNEDHQPAIKVVKGGAPQGSEHGVDGLSGATLTSNGVQHTFDFWLGDKGFGPFLAKVRDGELN | ||||||
Modified residue | 224 | FMN phosphoryl threonine | ||||
Sequence: T |
Keywords
- PTM
Interaction
Subunit
Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length256
- Mass (Da)27,703
- Last updated2007-01-23 v3
- Checksum150DCD862BCB7CE7
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 184 | in Ref. 1; CAA85478 | ||||
Sequence: W → R |
Keywords
- Technical term