Q56577 · NHAB_VIBAL

  • Protein
    Na(+)/H(+) antiporter NhaB
  • Gene
    nhaB
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Na+/H+ antiporter that extrudes sodium in exchange for external protons.

Catalytic activity

Features

Showing features for site.

152850100150200250300350400450500
TypeIDPosition(s)Description
Site147Important for antiport activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionsodium:proton antiporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Na(+)/H(+) antiporter NhaB
  • Alternative names
    • Sodium/proton antiporter NhaB

Gene names

    • Name
      nhaB

Organism names

  • Taxonomic identifier
  • Strain
    • 138-2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio

Accessions

  • Primary accession
    Q56577

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-23Cytoplasmic
Transmembrane24-46Helical
Topological domain47-95Periplasmic
Transmembrane96-118Helical
Topological domain119-129Cytoplasmic
Transmembrane130-163Helical
Topological domain164-239Periplasmic
Transmembrane240-262Helical
Topological domain263-297Cytoplasmic
Transmembrane298-317Helical
Topological domain318-320Periplasmic
Transmembrane321-340Helical
Topological domain341-352Cytoplasmic
Transmembrane353-375Helical
Topological domain376-389Periplasmic
Transmembrane390-412Helical
Topological domain413-477Cytoplasmic
Transmembrane478-500Helical
Topological domain501-528Periplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis147Loss of antiport activity at pH 8.5. No change in activity at pH 7.0.
Mutagenesis147Loss of antiport activity, both at pH 8.5 and at pH 7.0.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003331441-528Na+/H+ antiporter NhaB

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    528
  • Mass (Da)
    57,215
  • Last updated
    1996-11-01 v1
  • Checksum
    469F007E38688C6E
MPISLGNAFIKNFLGKAPDWYKVAIIAFLIINPIVFFLINPFVAGWLLVAEFIFTLAMALKCYPLQPGGLLAIEAIAIGMTSPAQVKHELVANIEVLLLLVFMVAGIYFMKHLLLFIFTKILLGIRSKTLLSLAFCFAAAFLSAFLDALTVIAVVISVAIGFYSIYHKVASGNPIGDHDHTQDDTITELTRDDLENYRAFLRSLLMHAGVGTALGGVTTMVGEPQNLIIADQAGWLFGEFLIRMSPVTLPVFFCGLITCALVEKLKVFGYGAKLPNNVRQILVDFDNEERKTRTNQDVAKLWVQGLIAVWLIVALALHLAAVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALLAVFFSIVAVIIDQELFKPVIDAVLAVEDKGTQLALFYVANGLLSMVSDNVFVGTVYINEVKTALIEGLITREQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVIMALPYTIVLAIVGLMGIMFFLEPATASFYDAGWILPHSGDLTPVVSGGH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D83728
EMBL· GenBank· DDBJ
BAA12086.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp