Q53B52 · 3SXZ_OPHHA

Function

function

This three-finger toxin binds and inhibits the nicotinic acetylcholine receptor (nAChR).

Miscellaneous

Is classified as a P-type cytotoxin, since a proline residue stands at position 49 (Pro-31 in standard classification).

Features

Showing features for site.

17810203040506070
MKNLLLTFLVVTIVCLDLGYTLICHQRHGLQTCEPAQKFCFAQTVMPFPNHPLTLMGCTYSCPTEKNAVCCSTDKCNR
TypeIDPosition(s)Description
Site28Important residue for inhibition of muscle alpha-1-beta-1-delta-epsilon and neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR
Site44Key residue for inhibition of muscle alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChR
Site46Key residue for inhibition of muscle alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) and important for inhibition of neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR
Site48Key residue for inhibition of muscle alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) and important residue for inhibition of neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR
Site51Important residue for inhibition of muscle alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) and neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR
Site66Important residue for inhibition of muscle alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) and neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionacetylcholine receptor inhibitor activity
Molecular Functionion channel regulator activity
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Short neurotoxin OH-26
  • Alternative names
    • Three-finger toxin (3FTx)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Elapinae > Ophiophagus

Accessions

  • Primary accession
    Q53B52

Subcellular Location

Keywords

Phenotypes & Variants

Toxic dose

LD50 is 160 ug/kg by intraperitoneal injection into mice.

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_500009332622-78Short neurotoxin OH-26
Disulfide bond24↔40
Disulfide bond33↔58
Disulfide bond62↔70
Disulfide bond71↔76

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    78
  • Mass (Da)
    8,756
  • Last updated
    2005-05-24 v1
  • Checksum
    1FDF616466E58123
MKNLLLTFLVVTIVCLDLGYTLICHQRHGLQTCEPAQKFCFAQTVMPFPNHPLTLMGCTYSCPTEKNAVCCSTDKCNR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY596934
EMBL· GenBank· DDBJ
AAT97256.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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