Q52NF0 · Q52NF0_STALI

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Chrysomeloidea > Chrysomelidae > Bruchinae > Bruchini > Stator

Accessions

  • Primary accession
    Q52NF0

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-37Helical
Transmembrane58-80Helical
Transmembrane100-125Helical
Transmembrane137-164Helical
Transmembrane184-209Helical
Transmembrane221-245Helical
Transmembrane257-279Helical
Transmembrane291-313Helical
Transmembrane333-355Helical
Transmembrane362-381Helical
Transmembrane401-427Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-431Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    431
  • Mass (Da)
    47,418
  • Last updated
    2005-05-24 v1
  • Checksum
    2AE2E8E041226E26
LIGNDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLLSSLVESGAGTGWTVYPPLAANIAHGGSSVDLAIFSLHLAGISSILGAVNFITTVINMRPQGMSMDRMPLFSWAVVITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGKKEAFGTLGMIYAMMAIGLLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKVFSWLATFHGTQILNSPVTLWALGFVFLFTVGGLTGVILANSSIDIVLHDTYYVVAHFHYVLSMGAVFAIMAGIVQWFPLFTGLTLNNFFLKIHFIVMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAFMIWNIVSSIGSIISLIGIVFFLFILWESFS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue431

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY997326
EMBL· GenBank· DDBJ
AAX94077.1
EMBL· GenBank· DDBJ
Genomic DNA
AY997333
EMBL· GenBank· DDBJ
AAX94084.1
EMBL· GenBank· DDBJ
Genomic DNA
AY997340
EMBL· GenBank· DDBJ
AAX94091.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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