Q4WED7 · XANE_ASPFU

Function

function

O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives (PubMed:29844112).
The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB (PubMed:29844112).
Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB (PubMed:29844112).
Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which introduces N-formyl groups and the methyltransferase xanE which introduces methyl groups, leading to the production of several derivatives including fumiformamide (PubMed:29844112).
Finally, fumiformamide can be subject to both oxidative and reductive cyclization to yield melanocins E and F, respectively (PubMed:29844112).

Pathway

Secondary metabolite biosynthesis.

Features

Showing features for binding site, active site.

143150100150200250300350400
TypeIDPosition(s)Description
Binding site283S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site330Proton acceptor

GO annotations

AspectTerm
Molecular FunctionO-methyltransferase activity
Biological Processmethylation
Biological Processsecondary metabolite biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    O-methyltransferase xanE
  • EC number
  • Alternative names
    • Xanthocillin biosynthesis cluster protein E

Gene names

    • Name
      xanE
    • ORF names
      AFUA_5G02640

Organism names

Accessions

  • Primary accession
    Q4WED7

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004452971-431O-methyltransferase xanE

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    431
  • Mass (Da)
    47,750
  • Last updated
    2005-07-05 v1
  • Checksum
    1A8602775A218751
MSTQHGPKSTRTNDLYELAVNISSTVEAFVGRLDAIGAERPNLDNPFPEIIQDEGAQLARLKILRLCERLMALVQGPVQWLMFQNMAFLDAACVGAILDMGIHDIIAPGPEPTSLDQIVEATGASKDILKRIMRVCTQRLVFDEIAPEQFIHNGVSLQFLAPPVQALISHACDDGLRMAAHFTDSLKKTDWKGSDDPENTAFSLAFNTNKGLFDYFYTEDLARGQRFALGMAGSEIMKTLTEDMFPFESLPQGAKVVDVGGGRGHVSVRIAEKVPGLNFVVQDDESMLEAGQAEGVPKAVKDRIEFMPHDFFNEQPVKGADVYLLRFILHDHSDSRCAKILSNIVDAMEPGKSRILIDDAIVPSFLGPESSRFFNLLDLYMLAGLNGKERTLEQWNYLIQMVSPKLVLEKVWKTPNGGPESGTILELRLQE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHF01000011
EMBL· GenBank· DDBJ
EAL86040.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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