Q4QMP4 · ISPD_HAEI8
- Protein2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- GeneispD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids225 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Catalytic activity
- 2-C-methyl-D-erythritol 4-phosphate + CTP + H+ = 4-CDP-2-C-methyl-D-erythritol + diphosphate
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 17 | Transition state stabilizer | ||||
Sequence: R | ||||||
Site | 24 | Transition state stabilizer | ||||
Sequence: K | ||||||
Site | 150 | Positions MEP for the nucleophilic attack | ||||
Sequence: R | ||||||
Site | 206 | Positions MEP for the nucleophilic attack | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus
Accessions
- Primary accessionQ4QMP4
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000237793 | 1-225 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | |||
Sequence: MTRSIIAVLPAAGVGSRMQADKPKQYLTLLGKTLLEHTLDVMLSYPAVSKIILAVSKDDPYISTLSLDPKIQLVEGGTTRAESVLNGLNAIAEKNAWVLVHDAARPCLQHADIDKLLAIEDKQGAILAIPVTDTIKRADNQQCIVKTEDRSQLWQAMTPQFFPVDILRDALSTGIQQGANITDEASAIELAGFRPHLVAGRSDNLKVTRPEDLALAEFYLTRNKL |
Structure
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)24,578
- Last updated2005-07-19 v1
- Checksum1A25BF307E307F06
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000057 EMBL· GenBank· DDBJ | AAX87703.1 EMBL· GenBank· DDBJ | Genomic DNA |