Q47LJ6 · RL2_THEFY
- ProteinLarge ribosomal subunit protein uL2
- GenerplB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids277 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosolic large ribosomal subunit | |
Molecular Function | rRNA binding | |
Molecular Function | structural constituent of ribosome | |
Molecular Function | transferase activity | |
Biological Process | cytoplasmic translation |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameLarge ribosomal subunit protein uL2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Nocardiopsaceae > Thermobifida
Accessions
- Primary accessionQ47LJ6
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000237258 | 1-277 | Large ribosomal subunit protein uL2 | |||
Sequence: MGIRKYKPTSPGRRGGSVSTFAEITRSKPEKSLVRPLHSKGGRNGHGRITARHQGGGHKRAYRLIDFRRHDKDGIPAKVAHIEYDPNRTARIALLHYVDGEKRYILAPVGLKQGDRVENGPAADIKPGNCLPLRNIPTGTFVHAVELKPGGGAKLGRAAGAAIQLLAKEGAYATLRMPSGEMRQVEVACRATVGQVGNVEHANISWGKAGRMRWKGKRPSVRGVAMNPIDHPHGGGEGRTSGGRHPVSPWGKAEGRTRKKGKPSDRLIVRRRSKKKR |
Interaction
Subunit
Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-55 | Disordered | ||||
Sequence: MGIRKYKPTSPGRRGGSVSTFAEITRSKPEKSLVRPLHSKGGRNGHGRITARHQG | ||||||
Compositional bias | 41-55 | Basic residues | ||||
Sequence: GGRNGHGRITARHQG | ||||||
Region | 217-277 | Disordered | ||||
Sequence: KRPSVRGVAMNPIDHPHGGGEGRTSGGRHPVSPWGKAEGRTRKKGKPSDRLIVRRRSKKKR | ||||||
Compositional bias | 263-277 | Basic residues | ||||
Sequence: PSDRLIVRRRSKKKR |
Sequence similarities
Belongs to the universal ribosomal protein uL2 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)30,146
- Last updated2005-09-13 v1
- Checksum688A84AD255002B2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 41-55 | Basic residues | ||||
Sequence: GGRNGHGRITARHQG | ||||||
Compositional bias | 263-277 | Basic residues | ||||
Sequence: PSDRLIVRRRSKKKR |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000088 EMBL· GenBank· DDBJ | AAZ56676.1 EMBL· GenBank· DDBJ | Genomic DNA |