Q3SK74 · HLDD_THIDA

Function

function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.

Catalytic activity

Cofactor

NADP+ (UniProtKB | Rhea| CHEBI:58349 )

Note: Binds 1 NADP+ per subunit.

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13-14NADP+ (UniProtKB | ChEBI)
Binding site34-35NADP+ (UniProtKB | ChEBI)
Binding site41NADP+ (UniProtKB | ChEBI)
Binding site56NADP+ (UniProtKB | ChEBI)
Binding site78-82NADP+ (UniProtKB | ChEBI)
Binding site95NADP+ (UniProtKB | ChEBI)
Active site142Proton acceptor
Binding site146NADP+ (UniProtKB | ChEBI)
Binding site171substrate
Binding site172NADP+ (UniProtKB | ChEBI)
Active site180Proton acceptor
Binding site180NADP+ (UniProtKB | ChEBI)
Binding site182substrate
Binding site189substrate
Binding site203-206substrate
Binding site216substrate
Binding site295substrate

GO annotations

AspectTerm
Molecular FunctionADP-glyceromanno-heptose 6-epimerase activity
Molecular FunctionNADP binding
Biological ProcessADP-L-glycero-beta-D-manno-heptose biosynthetic process
Biological Processcarbohydrate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-L-glycero-D-manno-heptose-6-epimerase
  • EC number
  • Alternative names
    • ADP-L-glycero-beta-D-manno-heptose-6-epimerase
      (ADP-glyceromanno-heptose 6-epimerase
      ; ADP-hep 6-epimerase
      ; AGME
      )

Gene names

    • Name
      hldD
    • Ordered locus names
      Tbd_0963

Organism names

Accessions

  • Primary accession
    Q3SK74

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002557461-332ADP-L-glycero-D-manno-heptose-6-epimerase

Interaction

Subunit

Homopentamer.

Protein-protein interaction databases

Structure

Family & Domains

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    332
  • Mass (Da)
    37,011
  • Last updated
    2005-10-11 v1
  • Checksum
    4CC07CCC378B5BF5
MSQYTVVTGAAGFIGANIVKALNERGETNIIAVDNLTKADKFKNLTDCEIADYLDKTEFLSVVEEGVLDGSVAAIFHEGACSDTMETDGRYMMDNNYRYSGALLKFCQDEGAQFLYASSASVYGSGRVFSESRECESPLNVYGYSKFLFDQSVRRLWAERTAQIAGFRYFNVYGPREQHKGRMASVAFHFFNQYRAEGRVKLFEGCDGYPNGEQRRDFVSVEDVVRVNMWFLDHPEVSGIFNVGTGRCQSFNDVAVATVNACRAAEGQDALTLDEMQAQGLIGYVAFPEALKGKYQSYTEADTAALRRAGYDGSFYSVEEGTARYIERLLQS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000116
EMBL· GenBank· DDBJ
AAZ96916.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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