Q3SK74 · HLDD_THIDA
- ProteinADP-L-glycero-D-manno-heptose-6-epimerase
- GenehldD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids332 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Catalytic activity
- ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
Cofactor
Note: Binds 1 NADP+ per subunit.
Pathway
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 13-14 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: FI | ||||||
Binding site | 34-35 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: DN | ||||||
Binding site | 41 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 56 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 78-82 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: EGACS | ||||||
Binding site | 95 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 142 | Proton acceptor | ||||
Sequence: Y | ||||||
Binding site | 146 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 171 | substrate | ||||
Sequence: N | ||||||
Binding site | 172 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Active site | 180 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 180 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 182 | substrate | ||||
Sequence: R | ||||||
Binding site | 189 | substrate | ||||
Sequence: H | ||||||
Binding site | 203-206 | substrate | ||||
Sequence: FEGC | ||||||
Binding site | 216 | substrate | ||||
Sequence: R | ||||||
Binding site | 295 | substrate | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ADP-glyceromanno-heptose 6-epimerase activity | |
Molecular Function | NADP binding | |
Biological Process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process | |
Biological Process | carbohydrate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameADP-L-glycero-D-manno-heptose-6-epimerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Nitrosomonadales > Thiobacillaceae > Thiobacillus
Accessions
- Primary accessionQ3SK74
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000255746 | 1-332 | ADP-L-glycero-D-manno-heptose-6-epimerase | |||
Sequence: MSQYTVVTGAAGFIGANIVKALNERGETNIIAVDNLTKADKFKNLTDCEIADYLDKTEFLSVVEEGVLDGSVAAIFHEGACSDTMETDGRYMMDNNYRYSGALLKFCQDEGAQFLYASSASVYGSGRVFSESRECESPLNVYGYSKFLFDQSVRRLWAERTAQIAGFRYFNVYGPREQHKGRMASVAFHFFNQYRAEGRVKLFEGCDGYPNGEQRRDFVSVEDVVRVNMWFLDHPEVSGIFNVGTGRCQSFNDVAVATVNACRAAEGQDALTLDEMQAQGLIGYVAFPEALKGKYQSYTEADTAALRRAGYDGSFYSVEEGTARYIERLLQS |
Interaction
Structure
Family & Domains
Domain
Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
Sequence similarities
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length332
- Mass (Da)37,011
- Last updated2005-10-11 v1
- Checksum4CC07CCC378B5BF5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000116 EMBL· GenBank· DDBJ | AAZ96916.1 EMBL· GenBank· DDBJ | Genomic DNA |