Q3AV04 · COXX_SYNS9
- ProteinProtoheme IX farnesyltransferase
- GenectaB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids326 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous
Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Catalytic activity
- (2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o
Pathway
Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | protoheme IX farnesyltransferase activity | |
Biological Process | heme O biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtoheme IX farnesyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Synechococcaceae > Synechococcus
Accessions
- Primary accessionQ3AV04
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 35-55 | Helical | ||||
Sequence: LIPLLLATTLGGMALTEGWPL | ||||||
Transmembrane | 60-80 | Helical | ||||
Sequence: LICTLGGGALASAAAGVLNCL | ||||||
Transmembrane | 106-126 | Helical | ||||
Sequence: TAFIGAIACTLVAAMLLVSGV | ||||||
Transmembrane | 129-149 | Helical | ||||
Sequence: LAAGLSLLGLCSYVLLYTALL | ||||||
Transmembrane | 157-177 | Helical | ||||
Sequence: IVVGGVAGAIPPLVGAAAATG | ||||||
Transmembrane | 185-205 | Helical | ||||
Sequence: WLFALVMVWTPAHFWALALLL | ||||||
Transmembrane | 238-258 | Helical | ||||
Sequence: VLLSGFGILALPTGGLFYGLM | ||||||
Transmembrane | 289-309 | Helical | ||||
Sequence: WSILYLFGICLLLILSRSALA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000327175 | 1-326 | Protoheme IX farnesyltransferase | |||
Sequence: MAEVTATVALTRADVVPSRKRVKLPAWLEVAKPRLIPLLLATTLGGMALTEGWPLSSPRLICTLGGGALASAAAGVLNCLWEQDLDGRMNRTSGRALPSGRLSPTTAFIGAIACTLVAAMLLVSGVNCLAAGLSLLGLCSYVLLYTALLKPRTTQNIVVGGVAGAIPPLVGAAAATGHIGLGGWWLFALVMVWTPAHFWALALLLREDYRAVGIPMLPVVKGPVVTARAISRYGWATVLLSGFGILALPTGGLFYGLMLLPYNNRLLQLVHRLAADPDSLTNAKSLFRWSILYLFGICLLLILSRSALAAHLDQQMIAMLMQLSVA |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length326
- Mass (Da)34,441
- Last updated2005-11-22 v1
- ChecksumD2A8D5579C85220C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000097 EMBL· GenBank· DDBJ | ABB26709.1 EMBL· GenBank· DDBJ | Genomic DNA |