Q2K3R7 · SECA_RHIEC
- ProteinProtein translocase subunit SecA
- GenesecA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids904 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Catalytic activity
Cofactor
Note: May bind 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 89 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 107-111 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GEGKT | ||||||
Binding site | 502 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 886 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 888 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 897 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 898 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell envelope Sec protein transport complex | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein-exporting ATPase activity | |
Biological Process | intracellular protein transmembrane transport | |
Biological Process | protein import | |
Biological Process | protein targeting | |
Biological Process | protein transport by the Sec complex |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein translocase subunit SecA
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Rhizobium
Accessions
- Primary accessionQ2K3R7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Peripheral membrane protein
Note: Distribution is 50-50.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000320914 | 1-904 | Protein translocase subunit SecA | |||
Sequence: MVSFGGIARKLFGSSNDRRVRSYQPNVAAINSIEEKTKALTDEQLAAKTVEFRALLAEGKTLDDILIPAFAVVREASRRVLGLRPFDVQLIGGMILHSNAIAEMKTGEGKTLVATLPVYLNALSGKGVHVVTVNDYLAQRDAATMGRVYGFLGMTTGVIVHGLSDEERRAAYACDITYATNNELGFDYLRDNMKYEKNQMVQRGHNFAIVDEVDSILVDEARTPLIISGPLDDRSELYNTIDAFIPLLAPSDYEIDEKQRSANFSEEGTEKLENLLRQAGLLKGNALYDIENVAIVHHINNALKAHKLFQRDKDYIVRNDEVVIIDEFTGRMMPGRRYSEGQHQALEAKEKVQIQPENQTLASITFQNYFRMYDKLAGMTGTAQTEAEEFGNIYNLDVIEVPTNLPIKRIDEDDEVYRTFDEKFKAIIEEILDAHKRGQPVLVGTTSIEKSELLAERMRKQGFNDFQVLNARYHEQEAYIVAQAGVPGAVTIATNMAGRGTDIQLGGNLDMRIERELGELEAGPERDARVQAIVEEIKELKQKALAAGGLYVIATERHESRRIDNQLRGRSGRQGDPGRSKFYLSLQDDLMRIFGSDRMDSMLTKLGLKEGEAIVHPWINKALERAQKKVEARNFDIRKNLLKYDDVLNDQRKVIFEQRLELMESTNISETVSDMRREVIEDLVEKHIPERAYAEQWDAVGLKTGVANILNLDLPIEEWFKEEGIGEDDIRERLTQAANAAFTEKAERFGDDIMHYVERSIVMQTLDHLWREHIVNLDHLRSVIGFRGYAQRDPLQEYKSEAFELFTGLLNNLREAVTAQLMRVELVQQAPAEPEPPLMQAHHLDPTTGEDDFAPIYQASEVIVSPENRNPEDPTTWGKVGRNEACPCGSGKKYKHCHGAFEQV |
Interaction
Subunit
Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
Structure
Sequence
- Sequence statusComplete
- Length904
- Mass (Da)102,158
- Last updated2006-03-07 v1
- Checksum97C9D7D2BFB44C2B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000133 EMBL· GenBank· DDBJ | ABC92519.1 EMBL· GenBank· DDBJ | Genomic DNA |