Q2G8K8 · PYRH_NOVAD
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids244 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- ATP + UMP = ADP + UDP
Activity regulation
Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 16-19 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KLSG | ||||||
Binding site | 58 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 59 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 63 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 78 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 139-146 | UMP (UniProtKB | ChEBI) | ||||
Sequence: VGAPYFTT | ||||||
Binding site | 166 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 172 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 175 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Novosphingobium
Accessions
- Primary accessionQ2G8K8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000053968 | 1-244 | Uridylate kinase | |||
Sequence: MSLPSCVPGYRRILLKLSGEVLMGEQQFGIDTDYVARVAQEVKDARDSGLEICLVIGGGNIFRGMAGAAKGMDRAQADYMGMLATVMNALAMQSALEQLGVPTRVQSAIEMDKVCEPVIRRRAERHLEKGRIVIFAAGVGAPYFTTDSGAALRAAEMKCDALLKGTSVDGVYNADPKKDPAAKRYETVDYDTVLADNLKVMDASAVALCRDNNIPIVVFSIRERGNLARVLAGEGTQTTVKKEA |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length244
- Mass (Da)26,248
- Last updated2006-03-21 v1
- ChecksumFAF42119402C389F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000248 EMBL· GenBank· DDBJ | ABD25815.1 EMBL· GenBank· DDBJ | Genomic DNA |