Q26427 · FIBL_GALME

Function

function

It is likely that the major role of L-chain is to prevent the retention of H-chain in ER by forming the disulfide linkage.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region

Keywords

Names & Taxonomy

Protein names

Gene names

    • Name
      FIBL

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Pyraloidea > Pyralidae > Galleriinae > Galleria

Accessions

  • Primary accession
    Q26427

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, modified residue, disulfide bond.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_000002125717-267Fibroin light chain
Modified residue19N-acetylserine; in short form
ChainPRO_000038956019-267Fibroin light chain, short form
Disulfide bond103↔162
Disulfide bond195Interchain (with heavy chain)

Post-translational modification

Partially N-terminally processed to yield a short form which lacks the first two residues of the long form.
The interchain disulfide bridge is essential for the intracellular transport and secretion of fibroin.

Keywords

Expression

Tissue specificity

Produced exclusively in the posterior (PSG) section of silk glands, which are essentially modified salivary glands.

Developmental stage

Expressed in the posterior silk glands throughout the penultimate and last larval instars. Declines in immobile pupae and disappears within the next 12 hours when insects pupate.

Interaction

Subunit

Silk fibroin elementary unit consists in a disulfide-linked heavy and light chain and a p25 glycoprotein in molar ratios of 6:6:1. This results in a complex of approximately 2.3 MDa.

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    267
  • Mass (Da)
    27,079
  • Last updated
    1996-11-01 v1
  • Checksum
    2A01050F9F120F6F
MLPFVLVLLVATSALAAPSVVISQDNINNIAPRVGNGRPISSALIDRAFEIVDGGDTNIYILTIQQILNDLADQPDGLSQSLAVTQAVAALGELATGVPGNSCEAAAVIDAYANSVRTGDNSALSIAVANYINRLSSNIGLISQLASNPDSLRYSSGPAGNCAGGGRSYQFEAAWDAVLNNANPYQIGLINEEYCAARRLYNAFNSRSNNVGAAITAGAVVAQTQAAQIILPSLVNVLSAVAAGGNVAGAAAQAGQALANAAANVQL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict24in Ref. 1; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
S77817
EMBL· GenBank· DDBJ
AAB34044.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp