Q26427 · FIBL_GALME
- ProteinFibroin light chain
- GeneFIBL
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids267 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
It is likely that the major role of L-chain is to prevent the retention of H-chain in ER by forming the disulfide linkage.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameFibroin light chain
- Short namesFib-L
- Alternative names
- Cleaved into 1 chains
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Pyraloidea > Pyralidae > Galleriinae > Galleria
Accessions
- Primary accessionQ26427
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, modified residue, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MLPFVLVLLVATSALA | ||||||
Chain | PRO_0000021257 | 17-267 | Fibroin light chain | |||
Sequence: APSVVISQDNINNIAPRVGNGRPISSALIDRAFEIVDGGDTNIYILTIQQILNDLADQPDGLSQSLAVTQAVAALGELATGVPGNSCEAAAVIDAYANSVRTGDNSALSIAVANYINRLSSNIGLISQLASNPDSLRYSSGPAGNCAGGGRSYQFEAAWDAVLNNANPYQIGLINEEYCAARRLYNAFNSRSNNVGAAITAGAVVAQTQAAQIILPSLVNVLSAVAAGGNVAGAAAQAGQALANAAANVQL | ||||||
Modified residue | 19 | N-acetylserine; in short form | ||||
Sequence: S | ||||||
Chain | PRO_0000389560 | 19-267 | Fibroin light chain, short form | |||
Sequence: SVVISQDNINNIAPRVGNGRPISSALIDRAFEIVDGGDTNIYILTIQQILNDLADQPDGLSQSLAVTQAVAALGELATGVPGNSCEAAAVIDAYANSVRTGDNSALSIAVANYINRLSSNIGLISQLASNPDSLRYSSGPAGNCAGGGRSYQFEAAWDAVLNNANPYQIGLINEEYCAARRLYNAFNSRSNNVGAAITAGAVVAQTQAAQIILPSLVNVLSAVAAGGNVAGAAAQAGQALANAAANVQL | ||||||
Disulfide bond | 103↔162 | |||||
Sequence: CEAAAVIDAYANSVRTGDNSALSIAVANYINRLSSNIGLISQLASNPDSLRYSSGPAGNC | ||||||
Disulfide bond | 195 | Interchain (with heavy chain) | ||||
Sequence: C |
Post-translational modification
Partially N-terminally processed to yield a short form which lacks the first two residues of the long form.
The interchain disulfide bridge is essential for the intracellular transport and secretion of fibroin.
Keywords
- PTM
Expression
Tissue specificity
Produced exclusively in the posterior (PSG) section of silk glands, which are essentially modified salivary glands.
Developmental stage
Expressed in the posterior silk glands throughout the penultimate and last larval instars. Declines in immobile pupae and disappears within the next 12 hours when insects pupate.
Interaction
Subunit
Silk fibroin elementary unit consists in a disulfide-linked heavy and light chain and a p25 glycoprotein in molar ratios of 6:6:1. This results in a complex of approximately 2.3 MDa.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length267
- Mass (Da)27,079
- Last updated1996-11-01 v1
- Checksum2A01050F9F120F6F
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 24 | in Ref. 1; AA sequence | ||||
Sequence: Q → E |
Keywords
- Technical term