Q1MIY5 · NDK_RHIJ3
- ProteinNucleoside diphosphate kinase
- Genendk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids140 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 59 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 87 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 93 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 104 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 114 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 117 | Pros-phosphohistidine intermediate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | CTP biosynthetic process | |
Biological Process | GTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase
- EC number
- Short namesNDK ; NDP kinase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Rhizobium > Rhizobium johnstonii
Accessions
- Primary accessionQ1MIY5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000267795 | 1-140 | Nucleoside diphosphate kinase | |||
Sequence: MAIERTFSMIKPDATKRNLTGAITKMLEDAGLRVVASKRVWMSRREAEGFYAVHKDRPFFGELVEGMTSGPTIVQVLEGEGAILKNREIMGATNPANADEGTIRKVHALSIGENSVHGSDAPETAAQEIKYWFSDTEIVG |
Keywords
- PTM
Interaction
Subunit
Homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length140
- Mass (Da)15,323
- Last updated2006-05-30 v1
- Checksum9DB557CE12C59E63
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM236080 EMBL· GenBank· DDBJ | CAK07075.1 EMBL· GenBank· DDBJ | Genomic DNA |