Q12QA6 · METK_SHEDO

Function

function

Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 divalent ions per subunit.
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Pathway

Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site15ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site17Mg2+ (UniProtKB | ChEBI)
Binding site43K+ (UniProtKB | ChEBI)
Binding site56L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site99L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site164-166ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site230-231ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site239ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site239L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site245-246ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site262ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site266ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site270L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionmethionine adenosyltransferase activity
Biological Processone-carbon metabolic process
Biological ProcessS-adenosylmethionine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosylmethionine synthase
  • EC number
  • Short names
    AdoMet synthase
  • Alternative names
    • MAT
    • Methionine adenosyltransferase

Gene names

    • Name
      metK
    • Ordered locus names
      Sden_1082

Organism names

Accessions

  • Primary accession
    Q12QA6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003029751-383S-adenosylmethionine synthase

Interaction

Subunit

Homotetramer; dimer of dimers.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region99-109Flexible loop

Sequence similarities

Belongs to the AdoMet synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    383
  • Mass (Da)
    41,455
  • Last updated
    2006-08-22 v1
  • Checksum
    175E654CC92BAEB6
MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEVTTSAWVDIEEITRKTVREIGYTHSDMGFDADSCAVLNAIGKQSPDINQGVDRADPAEQGAGDQGLMFGYANNETDVLMPAPITYAHALVKRQSEVRKDGTLPWLRPDAKSQVTFAYEDGKIVGIDAIVLSTQHREDVTQADLIEGVMETIIKPVLPAQWLNKDTKYFINPTGRFVIGGPVGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSISIETFGTGKVSEEVLIKLVRQHFELRPYGLTAMLDLARPIYQQTAAYGHFGREGFPWEATDKAEMLRADAGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000302
EMBL· GenBank· DDBJ
ABE54370.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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